TY - JOUR
T1 - Cutting edge
T2 - IL-17D, a novel member of the IL-17 family, stimulates cytokine production and inhibits hemopoiesis
AU - Starnes, Trevor
AU - Broxmeyer, Hal E.
AU - Robertson, Michael J.
AU - Hromas, Robert
PY - 2002/7/15
Y1 - 2002/7/15
N2 - A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-κB-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.
AB - A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of endothelial cells with purified rIL-17D protein stimulated the production of IL-6, IL-8, and GM-CSF. The increased expression of IL-8 was found to be NF-κB-dependent. rIL-17D also demonstrated an inhibitory effect on hemopoiesis of myeloid progenitor cells in colony formation assays.
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U2 - 10.4049/jimmunol.169.2.642
DO - 10.4049/jimmunol.169.2.642
M3 - Article
C2 - 12097364
AN - SCOPUS:0037100263
SN - 0022-1767
VL - 169
SP - 642
EP - 646
JO - Journal of Immunology
JF - Journal of Immunology
IS - 2
ER -