Cutaneous T-cell and NK-cell lymphomas: The WHO-EORTC classification and the increasing recognition of specialized tumor types

Marsha C Kinney, Dan Jones

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Cases drawn from Session 5 of the 2005 Society for Hematopathology/European Association for Haematopathology Workshop on progress in T-cell and natural killer (NK)-cell malignancies are used as a framework to review the current classification of T-cell and NK-cell malignancies in skin. In comparison with the typical pattern and course of mycosis fungoides (MF), selected variants of MF that can be difficult to diagnose are discussed. Cutaneous CD30+ lymphoproliferative disorders are also presented in detail. Particular focus is placed on the recognition of rare but clinically more aggressive cytotoxic lymphomas in the skin. Overall, diagnostic pitfalls and new information regarding disease pathogenesis brought up by the Workshop cases are provided. In addition, a general approach to the diagnosis of cutaneous T-cell lymphomas is discussed.

Original languageEnglish (US)
Pages (from-to)670-686
Number of pages17
JournalAmerican Journal of Clinical Pathology
Volume127
Issue number5
DOIs
StatePublished - May 2007

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Natural Killer Cells
Lymphoma
Mycosis Fungoides
T-Lymphocytes
Skin
Education
Cutaneous T-Cell Lymphoma
Neoplasms
Lymphoproliferative Disorders

Keywords

  • CD30
  • Dermatitis
  • Mycosis fungoides
  • Natural killer cell
  • Skin lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

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abstract = "Cases drawn from Session 5 of the 2005 Society for Hematopathology/European Association for Haematopathology Workshop on progress in T-cell and natural killer (NK)-cell malignancies are used as a framework to review the current classification of T-cell and NK-cell malignancies in skin. In comparison with the typical pattern and course of mycosis fungoides (MF), selected variants of MF that can be difficult to diagnose are discussed. Cutaneous CD30+ lymphoproliferative disorders are also presented in detail. Particular focus is placed on the recognition of rare but clinically more aggressive cytotoxic lymphomas in the skin. Overall, diagnostic pitfalls and new information regarding disease pathogenesis brought up by the Workshop cases are provided. In addition, a general approach to the diagnosis of cutaneous T-cell lymphomas is discussed.",
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