Current update on combined hepatocellular-cholangiocarcinoma

Suresh Maximin, Dhakshina Moorthy Ganeshan, Alampady K. Shanbhogue, Manjiri K. Dighe, Matthew M. Yeh, Orpheus Kolokythas, Puneet Bhargava, Neeraj Lalwani

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Combined hepatocellular-cholangiocarcinoma is a rare but unique primary hepatic tumor with characteristic histology and tumor biology.Recent development in genetics and molecular biology support the fact that combined hepatocellular-cholangiocarcinoma is closely linked withcholangiocarcinoma, rather than hepatocellular carcinoma. Combined hepatocellular cholangiocarcinoma tends to present with an more aggressive behavior and a poorer prognosis than either hepatocellularcarcinoma or cholangiocarcinoma. An accurate preoperative diagnosis and aggressive treatment planning can play crucial roles in appropriate patientmanagement.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalEuropean Journal of Radiology Open
Issue number1
StatePublished - 2014


  • Cholangiocarcinoma
  • Cirrhosis
  • Computed tomography
  • Hepatocellular carcinoma
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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