@article{192fa46cfea64d2ab1e840ee26a2ed8d,
title = "Current Status of Epitranscriptomic Marks Affecting lncRNA Structures and Functions",
abstract = "Long non-coding RNAs (lncRNAs) belong to a class of non-protein-coding RNAs with their lengths longer than 200 nucleotides. Most of the mammalian genome is transcribed as RNA, yet only a small percent of the transcribed RNA corresponds to exons of protein-coding genes. Thus, the number of lncRNAs is predicted to be several times higher than that of protein-coding genes. Because of sheer number of lncRNAs, it is often difficult to elucidate the functions of all lncRNAs, especially those arising from their relationship to their binding partners, such as DNA, RNA, and proteins. Due to their binding to other macromolecules, it has become evident that the structures of lncRNAs influence their functions. In this regard, the recent development of epitranscriptomics (the field of study to investigate RNA modifications) has become important to further elucidate the structures and functions of lncRNAs. In this review, the current status of lncRNA structures and functions influenced by epitranscriptomic marks is discussed.",
keywords = "RNA-seq, epitranscriptomics, gene expression, lncRNA",
author = "Miller, {Henry E.} and Mirolyuba Ilieva and Bishop, {Alexander J.R.} and Shizuka Uchida",
note = "Funding Information: Author Contributions: H.E.M., M.I., A.J.R.B. and S.U. wrote the manuscript, generated figures, and approved the final version of this manuscript. All authors have read and agreed to the published version of the manuscript. Funding: This work was supported by grants from the Novo Nordisk Foundation (NNF18OC0033438 Funding: This work was supported by grants from the Novo Nordisk Foundation (NNF18OC0033438 to M.I. and S.U.); the National Institutes of Health (1R01CA241554 to A.J.R.B., F31AG072902 to H.E.M.); Stand Up to Cancer—Cancer Research UK (RT6187 to A.J.R.B); and the Foundation (Greehey graduate fellowship to H.E.M.). Greehey Family Foundation (Greehey graduate fellowship to H.E.M.). Acknowledgments: We would like to thank the members of Bioinformatics Research Network for Acknowledgments: We would like to thank the members of Bioinformatics Research Network for their continued support to further advance the development of bioinformatics and tools. their continued support to further advance the development of bioinformatics and tools. Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest. Funding Information: This work was supported by grants from the Novo Nordisk Foundation (NNF18OC0033438 to M.I. and S.U.); the National Institutes of Health (1R01CA241554 to A.J.R.B., F31AG072902 to H.E.M.); Stand Up to Cancer—Cancer Research UK (RT6187 to A.J.R.B); and the Greehey Family Foundation (Greehey graduate fellowship to H.E.M.). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
month = apr,
doi = "10.3390/ncrna8020023",
language = "English (US)",
volume = "8",
journal = "Non-coding RNA",
issn = "2311-553X",
publisher = "MDPI AG",
number = "2",
}