Current Status of Epitranscriptomic Marks Affecting lncRNA Structures and Functions

Henry E. Miller, Mirolyuba Ilieva, Alexander J.R. Bishop, Shizuka Uchida

Research output: Contribution to journalReview articlepeer-review

Abstract

Long non-coding RNAs (lncRNAs) belong to a class of non-protein-coding RNAs with their lengths longer than 200 nucleotides. Most of the mammalian genome is transcribed as RNA, yet only a small percent of the transcribed RNA corresponds to exons of protein-coding genes. Thus, the number of lncRNAs is predicted to be several times higher than that of protein-coding genes. Because of sheer number of lncRNAs, it is often difficult to elucidate the functions of all lncRNAs, especially those arising from their relationship to their binding partners, such as DNA, RNA, and proteins. Due to their binding to other macromolecules, it has become evident that the structures of lncRNAs influence their functions. In this regard, the recent development of epitranscriptomics (the field of study to investigate RNA modifications) has become important to further elucidate the structures and functions of lncRNAs. In this review, the current status of lncRNA structures and functions influenced by epitranscriptomic marks is discussed.

Original languageEnglish (US)
Article number23
JournalNon-coding RNA
Volume8
Issue number2
DOIs
StatePublished - Apr 2022

Keywords

  • RNA-seq
  • epitranscriptomics
  • gene expression
  • lncRNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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