Current serum lipoprotein levels and fMRI response to working memory in midlife

Mitzi M. Gonzales, Takashi Tarumi, Danielle E. Eagan, Hirofumi Tanaka, Fedora O. Biney, Andreana P. Haley

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Aims: Given that high cholesterol levels at midlife are a risk factor for future cognitive decline, the goal of the current study was to determine if cholesterol-related alterations in the cerebrovascular response to cognition could be detected at midlife. Methods: Forty adults, aged 40-60 years, performed a 2-Back working memory task during fMRI. The associations between serum total cholesterol, HDL-cholesterol, and total cholesterol/HDL-cholesterol concentrations to task-related activation intensity were modeled using multivariate multiple regression (two-tailed p < 0.02). Results: Higher levels of total cholesterol/HDL-cholesterol related to reduced working memory-related activation intensity in the left inferior parietal lobe, right superior frontal gyrus, and right middle frontal gyrus. Conclusion: These data provide preliminary support for a deleterious effect of elevated total cholesterol/HDL-cholesterol ratio on cerebrovascular support for cognition in midlife.

Original languageEnglish (US)
Pages (from-to)259-267
Number of pages9
JournalDementia and Geriatric Cognitive Disorders
Issue number4
StatePublished - May 2011
Externally publishedYes


  • Brain imaging
  • Cholesterol
  • Cognition
  • Cognitive impairment
  • Vascular causes
  • Working memory

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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