Aldosterone-producing adenomas account for approximately 0.5% of all cases of hypertension. The incidence of aldosterone-producing adenomas during pregnancy is much lower, as reflected by a total of 15 biochemically and pathologically confirmed case reports in the English literature. We report the diagnosis, surgical management, and outcome of a patient with an aldosterone-producing adenoma suspected at 20 weeks gestation. Uniquely, we document the biochemical profiles of aldosterone, plasma renin activity, and 18-hydroxycorticosterone before and after surgical resection of the aldosterone-producing adenoma and 6 weeks postpartum. Our case and compilation of the English literature demonstrate an historic trend toward enhanced confidence in diagnostic testing during pregnancy and, subsequently, early surgical referral.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism