Current developments in salivary diagnostics

Craig S. Miller, Joseph D. Foley, Alison L. Bailey, Charles L. Campell, Roger L. Humphries, Nicolaos Christodoulides, Pierre N. Floriano, Glennon Simmons, Bryon Bhagwandin, James W. Jacobson, Spencer W. Redding, Jeffrey L. Ebersole, John T. McDevitt

Research output: Contribution to journalReview article

192 Scopus citations

Abstract

Salivary diagnostics is an emerging field that has progressed through several important developments in the past decade, including the publication of the human salivary proteome and the infusion of federal funds to integrate nanotechnologies and microfluidic engineering concepts into developing compact point-of-care devices for rapid analysis of this secretion. In this article, we discuss some of these developments and their relevance to the prognosis, diagnosis and management of periodontitis, as an oral target, and cardiovascular disease, as a systemic example for the potential of these biodiagnostics. Our findings suggest that several biomarkers are associated with distinct biological stages of these diseases and demonstrate promise as practical biomarkers in identifying and managing periodontal disease, and acute myocardial infarction. The majority of these studies have progressed through biomarker discovery, with the identified molecules requiring more robust clinical studies to enable substantive validation for disease diagnosis. It is predicted that with continued advances in this field the use of a combination of biomarkers in multiplex panels is likely to yield accurate screening tools for these diagnoses in the near future.

Original languageEnglish (US)
Pages (from-to)171-189
Number of pages19
JournalBiomarkers in Medicine
Volume4
Issue number1
DOIs
StatePublished - Feb 1 2010

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Keywords

  • Acute myocardial infarction
  • Lab-on-a-chip
  • Periodontitis
  • Salivary diagnosis

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Miller, C. S., Foley, J. D., Bailey, A. L., Campell, C. L., Humphries, R. L., Christodoulides, N., Floriano, P. N., Simmons, G., Bhagwandin, B., Jacobson, J. W., Redding, S. W., Ebersole, J. L., & McDevitt, J. T. (2010). Current developments in salivary diagnostics. Biomarkers in Medicine, 4(1), 171-189. https://doi.org/10.2217/bmm.09.68