Current development of saliva/oral fluid-based diagnostics.

Chih Ko Yeh, Nicolaos J. Christodoulides, Pierre N. Floriano, Craig S. Miller, Jeffrey L. Ebersole, Shannon E. Weigum, John McDevitt, Spencer W. Redding

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

Saliva can be easily obtained in medical and non-medical settings, and contains numerous bio-molecules, including those typically found in serum for disease detection and monitoring. In the past two decades, the achievements of high-throughput approaches afforded by biotechnology and nanotechnology allow for disease-specific salivary biomarker discovery and establishment of rapid, multiplex, and miniaturized analytical assays. These developments have dramatically advanced saliva-based diagnostics. In this review, we discuss the current consensus on development of saliva/oral fluid-based diagnostics and provide a summary of recent research advancements of the Texas-Kentucky Saliva Diagnostics Consortium. In the foreseeable future, current research on saliva based diagnostic methods could revolutionize health care.

Original languageEnglish (US)
Pages (from-to)651-661
Number of pages11
JournalTexas dental journal
Volume127
Issue number7
StatePublished - Jul 2010

ASJC Scopus subject areas

  • Dentistry(all)

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