ä Gustilo-Anderson type-III open fractures remain a considerable cause of morbidity and amputation. ä Systemic antibiotic prophylaxis with cephalosporins was introduced in the 1970s and substantially reduced the prevalence of infectious complications following injury. ä The use of antibiotics with an extended gram-negative (EGN) spectrum, such as aminoglycosides, is controversial; however, they are commonly used in type-III open fractures. ä Emerging literature has suggested that EGN antibiotic prophylaxis for type-III open fractures may not reduce infectious complication rates. ä Reducing the routine use of EGN antibiotics may be an important component of antimicrobial stewardship in orthopaedic trauma to reduce bacterial resistance and thus more complicated infections.
ASJC Scopus subject areas
- Orthopedics and Sports Medicine