Current concepts in Cryptococcosis

T. F. Patterson, V. T. Andriole

Research output: Contribution to journalReview article

33 Scopus citations

Abstract

Cryptococcus neoformans has become an increasingly important pathogen. Cryptococcosis is an important cause of morbidity and mortality in immunocompromised hosts and is the second most common fungal infection complicating AIDS. In recent years, research has focused on the host defenses against Cryptococcus and has led to an improved understanding of the capsular virulence of the organism, the mechanisms of T-cell defenses, and the role of phagocytic cells in the fungistasis and killing of cryptococci. Amphotericin B with or without flucytosine has clearly improved treatment of cryptococcosis, but therapy is associated with significant toxicity. Current investigation is focused on the triazoles, which may offer improved therapy for cryptococcosis. In this report, we review recent developments in the understanding of the host defenses against Cryptococcocus and discuss current recommendations for the management of cryptococcosis.

Original languageEnglish (US)
Pages (from-to)457-465
Number of pages9
JournalEuropean Journal of Clinical Microbiology & Infectious Diseases
Volume8
Issue number5
DOIs
StatePublished - May 1 1989
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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