Curcumin ameliorates alveolar bone destruction of experimental periodontitis by modulating osteoclast differentiation, Activation and function

Lian Ping Mau, Wan Chien Cheng, Jen Kun Chen, Yi Shing Shieh, David L. Cochran, Ren Yeong Huang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

This study evaluated as to whether curcumin (CCM) could ameliorate alveolar bone destruction in vivo and dissect its mechanism in vitro. The tartrate-resistant acid phosphatase (TRAP) activity, TRAP staining, quantitative RT-PCR, gelatin zymography, actin-ring formation, and pits formation assay were used to analyse the effect of CCM on receptor activator of nuclear factor κB ligand (RANKL)-induced osteoclast differentiation, activation, and function. Porphyromonas gingivalis LPS- and ligature-induced experimental periodontitis were established to evaluate the therapeutic benefits of CCM in vivo. The results demonstrated that CCM dose dependently diminishes RANKL-induced osteoclast differentiation, and osteoclastic specific genes expression accompanied by a significant attenuation of actin-ring and resorptive pits formation in vitro. Moreover, CCM reduces alveolar bone destruction, decreases TRAP-positive and polymorphonuclear cells infiltration, and suppresses myeloperoxidase activity in vivo. Thus, CCM reduces inflammatory bone loss in vivo by modulating RANKL-mediated osteoclast differentiation, activation, and function.

Original languageEnglish (US)
Pages (from-to)243-256
Number of pages14
JournalJournal of Functional Foods
Volume22
DOIs
StatePublished - Apr 1 2016

Keywords

  • Bone resorption
  • Curcumin
  • Osteoclastogenesis
  • Periodontal disease

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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