Abstract
Curcumin, a natural polyphenol extract from Curcuma longa, has been considered one of the most promising and safe phytochemicals for glioblastoma therapy. During the last decade, innumerous in vitro and animal studies have provided evidence that curcumin modulates activation of several pathways (NFKB, JAK/STAT, MAPKs, NOTCH, NRF2, Sonic hedgehog among others) involved in the proliferation and chemoresistance of glioblastomas as well as those involved in disease progression (invasion, migration and angiogenesis). In this chapter, we will discuss some curcumin targeted pathways involved in glioblastomas development. Special focus will be given to the mechanisms whereby curcumin can modulate them in order to interfere with essential survival strategies used by these tumors.
Original language | English (US) |
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Title of host publication | Curcumin |
Subtitle of host publication | Synthesis, Emerging Role in Pain Management and Health Implications |
Publisher | Nova Science Publishers, Inc. |
Pages | 409-433 |
Number of pages | 25 |
ISBN (Electronic) | 9781633213302 |
ISBN (Print) | 9781633213197 |
State | Published - Jul 1 2014 |
Keywords
- Curcumin
- Glioblastomas
- Signaling pathways
- Survival
ASJC Scopus subject areas
- General Neuroscience