Curcumin: A broad spectrum inhibitor targeting pathways relevant to glioblastomas

Alfeu Zanotto-Filho, Alexander J Bishop, José Cláudio Fonseca Moreira

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Curcumin, a natural polyphenol extract from Curcuma longa, has been considered one of the most promising and safe phytochemicals for glioblastoma therapy. During the last decade, innumerous in vitro and animal studies have provided evidence that curcumin modulates activation of several pathways (NFKB, JAK/STAT, MAPKs, NOTCH, NRF2, Sonic hedgehog among others) involved in the proliferation and chemoresistance of glioblastomas as well as those involved in disease progression (invasion, migration and angiogenesis). In this chapter, we will discuss some curcumin targeted pathways involved in glioblastomas development. Special focus will be given to the mechanisms whereby curcumin can modulate them in order to interfere with essential survival strategies used by these tumors.

Original languageEnglish (US)
Title of host publicationCurcumin: Synthesis, Emerging Role in Pain Management and Health Implications
PublisherNova Science Publishers, Inc.
Pages409-433
Number of pages25
ISBN (Print)9781633213302, 9781633213197
StatePublished - Jul 1 2014

Keywords

  • Curcumin
  • Glioblastomas
  • Signaling pathways
  • Survival

ASJC Scopus subject areas

  • Neuroscience(all)

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