CSF and Urinary Biogenic Amines and Metabolites in Depression and Mania: A Controlled, Univariate Analysis

Stephen H. Koslow, James W. Maas, Charles L. Bowden, John M. Davis, Israel Hanin, Javaid Javaid

Research output: Contribution to journalArticle

252 Scopus citations

Abstract

Levels of 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in the CSF, and norepinephrine (NE), epinephrine (E), vanillylmandelic acid, normetanephrine, metanephrine, and MHPG in the urine, were measured in 151 hospitalized patients with affective disorders and in 80 healthy controls following a two-week drug-free period. Unipolar and bipolar depressed subjects differed only in NE and E levels. Compared with controls, depressed subjects had higher CSF MHPG levels, women had higher 5-HIAA levels, and men had lower HVA levels. All urinary metabolites were elevated in depression and mania, with the exception of MHPG. The patterns of NE-E differences discriminated among the forms of affective disorders. These data suggest an imbalance of monoamine transmission in depression, characterized by the hyperactive sympathetic nervous system and adrenal medulla. However, MHPG may not be the measure of choice to reflect this imbalance, necessitating measurement of total body monoamine output.

Original languageEnglish (US)
Pages (from-to)999-1010
Number of pages12
JournalArchives of General Psychiatry
Volume40
Issue number9
DOIs
StatePublished - Sep 1983

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

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