Cryoimmunotherapy in Urologic Oncology

Abhinav Sidana, Wasim H. Chowdhury, Ephraim J. Fuchs, Ronald Rodriguez

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Cryoablation is gaining acceptance as a primary treatment of localized as well as a salvage therapy of metastatic urologic malignancies. Anecdotal clinical reports suggest cryoablation can induce a systemic anti-tumor immune response; this phenomenon has been confirmed in animal models. To capitalize on this stimulatory effect of cryotherapy for control of advanced malignancies, it must be further intensified. This article reviews the existing evidence regarding cryoimmunology and discusses the mechanisms for generation of an anti-tumor immune response. Several immunotherapy approaches that can be combined with cryoablation to devise a cryoimmunotherapeutic strategy with potential to affect the progression of metastatic disease are described.

Original languageEnglish (US)
Pages (from-to)1009-1014
Number of pages6
JournalUrology
Volume75
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

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Cryosurgery
Neoplasms
Salvage Therapy
Cryotherapy
Immunotherapy
Disease Progression
Animal Models
Therapeutics

ASJC Scopus subject areas

  • Urology

Cite this

Sidana, A., Chowdhury, W. H., Fuchs, E. J., & Rodriguez, R. (2010). Cryoimmunotherapy in Urologic Oncology. Urology, 75(5), 1009-1014. https://doi.org/10.1016/j.urology.2009.06.020

Cryoimmunotherapy in Urologic Oncology. / Sidana, Abhinav; Chowdhury, Wasim H.; Fuchs, Ephraim J.; Rodriguez, Ronald.

In: Urology, Vol. 75, No. 5, 05.2010, p. 1009-1014.

Research output: Contribution to journalArticle

Sidana, A, Chowdhury, WH, Fuchs, EJ & Rodriguez, R 2010, 'Cryoimmunotherapy in Urologic Oncology', Urology, vol. 75, no. 5, pp. 1009-1014. https://doi.org/10.1016/j.urology.2009.06.020
Sidana, Abhinav ; Chowdhury, Wasim H. ; Fuchs, Ephraim J. ; Rodriguez, Ronald. / Cryoimmunotherapy in Urologic Oncology. In: Urology. 2010 ; Vol. 75, No. 5. pp. 1009-1014.
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