Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder

Barbara K. Chen, Roberto Sassi, David Axelson, John P. Hatch, Marsal Sanches, Mark Nicoletti, Paolo Brambilla, Matcheri S. Keshavan, Neal D. Ryan, Boris Birmaher, Jair C. Soares

Research output: Contribution to journalArticlepeer-review

129 Scopus citations

Abstract

In vivo imaging studies in adult bipolar patients have suggested enlargement of the amygdala. It is not known whether this abnormality is already present early in the illness course or whether it develops later in life. We conducted a morphometric MRI study to examine the size of specific temporal lobe structures in adolescents and young adults with bipolar disorder and healthy control subjects, as well as their relationship with age, to examine possible neurodevelopmental abnormalities. Subjects included 16 DSM-IV bipolar patients (16 ± 3 years) and 21 healthy controls (mean age ± SD = 17 ± 4 years). Measures of amygdala, hippocampus, temporal gray matter, temporal lobe, and intracranial volumes (ICV) were obtained. There was a trend to smaller left amygdala volumes in patients (mean volumes ± SD = 1.58 ± .42 mL) versus control subjects (1.83 ± .4 mL; F = 3.87, df = 1,32, p = .06). Bipolar patients did not show significant differences in right or left hippocampus, temporal lobe gray matter, temporal lobe, or right amygdala volumes (analysis of covariance, age, gender, and ICV as covariates, p > .05) compared with healthy control subjects. Furthermore, there was a direct correlation between left amygdala volumes and age (r =. 50, p =. 047) in patients, whereas in healthy controls there was an inverse correlation (r = -.48, p =. 03). The direct correlation between left amygdala volumes and age in bipolar patients, not present in healthy control subjects, may reflect abnormal developmental mechanisms in bipolar disorder.

Original languageEnglish (US)
Pages (from-to)399-405
Number of pages7
JournalBiological Psychiatry
Volume56
Issue number6
DOIs
StatePublished - Sep 15 2004

Keywords

  • Adolescence
  • MRI
  • affective disorders
  • development
  • mood disorders
  • neuroimaging

ASJC Scopus subject areas

  • Biological Psychiatry

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