Cross-sectional correlates of serum heat shock protein 70 in the community

Ravi Dhingra, Martin G. Larson, Emelia J. Benjamin, Isabella Lipinska, Philimon Gona, Diane Corey, John F. Keaney, Ramachandran S. Vasan

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: Recent studies of referral samples suggest that heat shock proteins play a key role in the pathogenesis of high BP and cardiovascular diseases (CVD) including heart failure. It is unclear whether circulating heat shock protein 70 (HSP70) levels are related to CVD risk factors, echocardiographic indexes of left ventricular (LV) remodeling, and prevalent CVD in the population. Methods: We evaluated the cross-sectional relations of serum HSP70 to established CVD risk factors (including hypertension), markers of oxidative stress (urinary 8-epi-PGF) and inflammation (plasma interleukin-6, C-reactive protein, monocyte chemoattractant protein-1 MCP-1, and soluble intercellular adhesion molecule sICAM-1), echocardiographic LV dimensions and prevalent CVD in 456 Framingham Offspring Study participants (mean age 61 years, 42% women). Results: In multivariable analyses, serum HSP70 was not associated with age, sex, vascular risk factors (including hypertension), echocardiographic LV mass or prevalent CVD. Also, serum HSP70 was not related to any of the biomarkers evaluated (p<0.10 for all). Conclusions: In our community-based sample, serum HSP70 was similar in men and women, and not significantly related to traditional or novel risk factors, to LV mass or to prevalent CVD. Our data suggest that blood levels may not adequately reflect the important role of heat shock proteins in prevalent CVD.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalAmerican Journal of Hypertension
Volume19
Issue number2
DOIs
StatePublished - Feb 2006
Externally publishedYes

Keywords

  • Cardiovascular disease
  • Epidemiology
  • Heat-shock proteins 70
  • Inflammation
  • Left ventricle

ASJC Scopus subject areas

  • Internal Medicine

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