Cross-sectional correlates of increased aortic stiffness in the community: The Framingham heart study

Gary F. Mitchell, Chao Yu Guo, Emelia J. Benjamin, Martin G. Larson, Michelle J. Keyes, Joseph A. Vita, Ramachandran S. Vasan, Daniel Levy

Research output: Contribution to journalArticlepeer-review

192 Scopus citations

Abstract

BACKGROUND - Increased aortic stiffness is associated with numerous common diseases of aging, including heart disease, stroke, and renal disease. However, the prevalence and correlates of abnormally high aortic stiffness are incompletely understood. METHODS AND RESULTS - We evaluated 2 aortic stiffness measures, carotid-femoral pulse wave velocity and forward pressure wave amplitude, in a pooled sample of the Framingham Original, Offspring, and minority Omni cohorts (mean age, 62 years; 56% women). Abnormal stiffness of each measure was defined as a value exceeding the sex-specific 90th percentile of a reference group with a low burden of conventional cardiovascular disease risk factors. Applying this criterion to the entire sample identified a 24% to 33% prevalence of abnormal stiffness measures. The prevalence of abnormal stiffness increased markedly with age, eg, for pulse wave velocity, from a few percent in both sexes aged <50 years to 64% (men) to 74% (women) in those aged ≥70 years. With adjustment for age, important correlates of abnormal aortic stiffness included higher mean arterial pressure, greater body mass index, impaired glucose metabolism, and abnormal lipids. Correlates of aortic stiffness were similar if we used age-specific rather than fixed criteria for defining abnormal stiffness. CONCLUSIONS - The prevalence of abnormal aortic stiffness increases steeply with advancing age in the community, especially in the presence of obesity or diabetes. Our data suggest that the burden of disease attributable to aortic stiffness is likely to increase considerably over the next few years as the population ages.

Original languageEnglish (US)
Pages (from-to)2628-2636
Number of pages9
JournalCirculation
Volume115
Issue number20
DOIs
StatePublished - May 2007
Externally publishedYes

Keywords

  • Arteriosclerosis
  • Blood pressure
  • Hypertension
  • Obesity
  • Population
  • Risk factors
  • Vasculature

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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