Cross-sectional comparison of health-span phenotypes in young versus geriatric marmosets

Corinna N. Ross, Jessica Adams, Olga Gonzalez, Edward Dick, Luis Giavedoni, Vida L. Hodara, Kimberley Phillips, Anna D. Rigodanzo, Balakuntalam Kasinath, Suzette D. Tardif

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The development of the marmoset as a translational model for healthspan and lifespan studies relies on the characterization of health parameters in young and geriatric marmosets. This cross-sectional study examined health phenotypes in marmosets for five domains of interest for human health and aging: mobility, cognition, metabolism, homeostasis, and immune function. Geriatric marmosets were found to have significant executive function impairment when compared to young animals. While geriatric animals did not show gross abnormalities in mobility and measures of locomotion, their types of movement were altered from young animals. Geriatric marmosets had alterations in cardiac function, with significantly increased mean arterial pressures; metabolism, with significantly lower VO 2 ; and suppressed immune function. Further, this study sought to characterize and describe histopathology for both young and geriatric healthy marmosets. Overall this study provides a characterization of health parameters for young and geriatric marmosets which will greatly enhance future aging and interventional testing in marmosets.

Original languageEnglish (US)
Article numbere22952
JournalAmerican Journal of Primatology
Volume81
Issue number2
DOIs
StatePublished - Feb 1 2019

Keywords

  • animal models
  • biomarkers of aging
  • healthspan
  • longevity
  • nonhuman primates

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Animal Science and Zoology

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