Cross-reactivity of the B B′ subunit of the Sm ribonucleoprotein autoantigen with proline-rich polypeptides

Filip De Keyser, Sallie O. Hoch, Masami Takei, Howard Dang, Heide De Keyser, Luis A. Rokeach, Norman Talal

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Using recombinant fusion proteins representing different regions of the human Sm B B′ polypeptide, the 4B4 monoclonal anti-Sm antibody was found to bind a C-terminus epitope that is proline-rich. 4B4 cross-reacted with the p24 gag protein of HIV-1 and with other polypeptides rich in proline residues, including collagen. BALB c mice immunized with human collagen not only produced antibodies to the immunizing antigen but also antibodies to Sm. This immune mouse serum also recognized C-terminus B B′ fusion proteins. These data suggest that the Sm B B′ antigen contains a poly-Pro epitope that is shared by several autoantigens and retroviral proteins. These sites may be important in the induction of autoantibodies through molecular mimicry.

Original languageEnglish (US)
Pages (from-to)285-290
Number of pages6
JournalClinical Immunology and Immunopathology
Volume62
Issue number3
DOIs
StatePublished - Mar 1992

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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