TY - JOUR
T1 - Creation of an Ex Vivo Renal Perfusion Model to Investigate Microwave Ablation
AU - Ortiz, Carlos B.
AU - Dang, Annie
AU - Derrick, Kade
AU - O'Donnell, Barrett
AU - Bitar, Ryan
AU - Parker, Matthew
AU - Veraza, Rafael
AU - Bunegin, Leonid
AU - Borrego, Marina
AU - Yamaguchi, Seiji
AU - Walker, John A.
AU - Lopera, Jorge
N1 - Funding Information:
R.V. is stockholder for Vascular Perfusion Solutions. L.B. is stockholder and Chief Scientific Officer for Vascular Perfusion Solutions. A.D. was provided training support by the South Texas Medical Scientist Training Program ( National Institutes of Health T32GM113896). The other authors have not identified a conflict of interest.
Publisher Copyright:
© 2022 SIR
PY - 2023/1
Y1 - 2023/1
N2 - This study hypothesized that an ex vivo renal perfusion model can create smaller microwave ablation (MWA) measurements during perfused states compared with nonperfused states across multiple device settings. Nine bovine kidneys, a fluoroscopic compatible perfusion model, and a commercially-available clinical MWA system were used to perform 72 ablations (36 perfused and 36 nonperfused) at 9 different device settings. Comparing perfused and nonperfused ablations at each device setting, significant differences in volume existed for 6 of 9 settings (P < .05). Collapsed across time settings, the ablation volumes by power were the following (perfused and nonperfused, P value): 60 W, 2.3 cm3 ± 1.0 and 7.2 cm3 ± 2.7, P < .001; 100 W, 5.4 cm3 ± 2.1 and 11.5 cm3 ± 5.6, P < .01; and 140 W, 11.2 cm3 ± 3.7 and 18.7 cm3 ± 6.3, P < .01. Applied power correlated with ablation volume: perfused, 0.021 cm3/W and R = 0.462, P = .004, and nonperfused, 0.029 cm3/W and R = 0.565, P < .001. These results support that an ex vivo perfused organ system can evaluate MWA systems and demonstrate heat sink perfusion effects of decreased ablation size.
AB - This study hypothesized that an ex vivo renal perfusion model can create smaller microwave ablation (MWA) measurements during perfused states compared with nonperfused states across multiple device settings. Nine bovine kidneys, a fluoroscopic compatible perfusion model, and a commercially-available clinical MWA system were used to perform 72 ablations (36 perfused and 36 nonperfused) at 9 different device settings. Comparing perfused and nonperfused ablations at each device setting, significant differences in volume existed for 6 of 9 settings (P < .05). Collapsed across time settings, the ablation volumes by power were the following (perfused and nonperfused, P value): 60 W, 2.3 cm3 ± 1.0 and 7.2 cm3 ± 2.7, P < .001; 100 W, 5.4 cm3 ± 2.1 and 11.5 cm3 ± 5.6, P < .01; and 140 W, 11.2 cm3 ± 3.7 and 18.7 cm3 ± 6.3, P < .01. Applied power correlated with ablation volume: perfused, 0.021 cm3/W and R = 0.462, P = .004, and nonperfused, 0.029 cm3/W and R = 0.565, P < .001. These results support that an ex vivo perfused organ system can evaluate MWA systems and demonstrate heat sink perfusion effects of decreased ablation size.
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U2 - 10.1016/j.jvir.2022.10.013
DO - 10.1016/j.jvir.2022.10.013
M3 - Article
C2 - 36244634
AN - SCOPUS:85142477209
VL - 34
SP - 40-45.e2
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
SN - 1051-0443
IS - 1
ER -