Abstract
Directed movement of stem cells is crucial not only for organogenesis during development, but also for tissue regeneration in adult life. This chapter presents examples of stem cell migration and recruitment and the application of cell homing in orofacial regeneration. Cell homing refers to the recruitment of endogenous cells, including stem and progenitor cells, into a wound. Homing can be local and/or systemic. Whereas cell homing via circulation has contributed a great deal to the knowledge of pathogenesis of diverse diseases, including infections and tumor metastasis, we understand little of how to immobilize and direct cell homing in tissue regeneration. Stem and progenitor cells are highlighted to demonstrate their migration, lineage commitment, and potential roles in wound healing.
Original language | English (US) |
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Title of host publication | Stem Cells in Craniofacial Development and Regeneration |
Publisher | John Wiley and Sons |
Pages | 367-378 |
Number of pages | 12 |
ISBN (Print) | 9781118279236 |
DOIs | |
State | Published - Mar 26 2013 |
Externally published | Yes |
Keywords
- Cell homing
- Cell migration
- Craniofacial tissue bioengineering
- Endogenous stem cells
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)