Craniofacial Tissue Bioengineering and Regeneration by Endogenous Stem Cells

Nan Jiang, Mo Chen, Chang Hun Lee, Jian Zhou, Mildred C. Embree, Kimi Kong, Choko Cho, Avital Mendelson, Ying Zheng, Hemin Nie, Jeremy J. Mao

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Directed movement of stem cells is crucial not only for organogenesis during development, but also for tissue regeneration in adult life. This chapter presents examples of stem cell migration and recruitment and the application of cell homing in orofacial regeneration. Cell homing refers to the recruitment of endogenous cells, including stem and progenitor cells, into a wound. Homing can be local and/or systemic. Whereas cell homing via circulation has contributed a great deal to the knowledge of pathogenesis of diverse diseases, including infections and tumor metastasis, we understand little of how to immobilize and direct cell homing in tissue regeneration. Stem and progenitor cells are highlighted to demonstrate their migration, lineage commitment, and potential roles in wound healing.

Original languageEnglish (US)
Title of host publicationStem Cells in Craniofacial Development and Regeneration
PublisherJohn Wiley and Sons
Pages367-378
Number of pages12
ISBN (Print)9781118279236
DOIs
StatePublished - Mar 26 2013
Externally publishedYes

Keywords

  • Cell homing
  • Cell migration
  • Craniofacial tissue bioengineering
  • Endogenous stem cells

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Craniofacial Tissue Bioengineering and Regeneration by Endogenous Stem Cells'. Together they form a unique fingerprint.

  • Cite this

    Jiang, N., Chen, M., Lee, C. H., Zhou, J., Embree, M. C., Kong, K., Cho, C., Mendelson, A., Zheng, Y., Nie, H., & Mao, J. J. (2013). Craniofacial Tissue Bioengineering and Regeneration by Endogenous Stem Cells. In Stem Cells in Craniofacial Development and Regeneration (pp. 367-378). John Wiley and Sons. https://doi.org/10.1002/9781118498026.ch20