Coxsackievirus group B antibodies in the ventricular fluid of infants with severe anatomic defects in the central nervous system

C. J. Gauntt, R. J. Gudvangen, Y. W. Brans, A. E. Marlin

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Ventricular fluids from four of 28 newborn infants who were initially seen with severe congenital anatomic defects in the central nervous system contained neutralizing antibody to at least one serotype of coxsackieviruses group B. Two of the four infants with anticoxsackieviruses group B antibody in the ventricular fluid did not have a detectable level of the same antibody(ies) in their serum. The ventricular fluid of one of the infants had immunoglobulin M neutralizing antibody directed against coxsackievirus B6. Of 11 mother-infant pairs that had neutralizing antibody to coxsackieviruses group B in both sera, nearly half had antibodies directed against more than one serotype. These data suggest the possibility of an association between congenital infections with coxsackieviruses group B and rare severe CNS defects.

Original languageEnglish (US)
Pages (from-to)64-68
Number of pages5
JournalPediatrics
Volume76
Issue number1
StatePublished - 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint

Dive into the research topics of 'Coxsackievirus group B antibodies in the ventricular fluid of infants with severe anatomic defects in the central nervous system'. Together they form a unique fingerprint.

Cite this