Coxsackievirus B3 infection alters plasma membrane of neonatal skin fibroblasts

C. W. Lutton, C. J. Gauntt

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Replication of coxsackievirus B3 occurred for days in cultures of murine neonatal skin fibroblasts in the absence of cytopathology and resulted in alteration of the plasma membrane. Dual immunofluorescence studies showed that the lectin Ulex europaeus agglutinin I bound only to cells producing viral capsid antigens. Cultures of coxsackievirus B3-inoculated murine neonatal skin fibroblasts showed maximum binding of this lectin at 72 h postinoculation. These data show that in a nonlytic infection a picornavirus can alter the surface of an infected cell.

Original languageEnglish (US)
Pages (from-to)294-296
Number of pages3
JournalJournal of virology
Volume60
Issue number1
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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