Cow's Milk Protein Allergy

Grace Mousan, Deepak Kamat

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Cow's milk protein allergy (CMPA) is a common condition encountered in children with incidence estimated as 2% to 7.5% in the first year of life. Formula and breast-fed babies can present with symptoms of CMPA. It is important to accurately diagnose CMPA to avoid the consequences of either under- or overdiagnosis. CMPA is classically categorized into immunoglobulin E (IgE)- or non-IgE-mediated reaction that vary in clinical manifestations, diagnostic evaluation, and prognosis. The most commonly involved systems in patients with CMPA are gastrointestinal, skin, and respiratory. Evaluation of CMPA starts with good data gathering followed by testing if indicated. Treatment is simply by avoidance of cow's milk protein (CMP) in the child's or mother's diet, if exclusively breast-feeding. This article reviews the definition, epidemiology, risk factors, pathogenesis, clinical presentation, evaluation, management, and prognosis of CMPA and provides an overview of different options for formulas and their indication in the treatment of CMPA.

Original languageEnglish (US)
Pages (from-to)1054-1063
Number of pages10
JournalClinical Pediatrics
Volume55
Issue number11
DOIs
StatePublished - Oct 1 2016
Externally publishedYes

Keywords

  • Allergic colitis
  • allergy
  • amino-acid based formula
  • breast-feeding
  • cow's milk
  • elimination diet
  • extensively hydrolyzed formula
  • formula feeding
  • oral challenge
  • protein

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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