Covalent binding of polycyclic aromatic hydrocarbons to adenine correlates with tumorigenesis in mouse skin

J. DiGiovanni, J. R. Romson, D. Linville, M. R. Juchau, T. J. Slaga

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Mouse epidermal homogenates were utilized to convert various polycyclic aromatic hydrocarbons to metabolites capable of binding covalently with nucleic acids. Poly(G) showed the highest capacity to bind covalently with the hydrocarbons; however, there was no correlation between binding to poly(G) and mouse skin tumorigenicity. On the other hand, covalent binding to poly(A) correlated well with values obtained for binding to DNA and mouse skin tumorigenicity. The order of binding to poly(A) was; 7,12-dimethylbenz[a]anthracene > benzo[a]pyrene > dibenz[a,h]anthracene > dibenz-[a,c]anthracene.

Original languageEnglish (US)
Pages (from-to)39-43
Number of pages5
JournalCancer Letters
Volume7
Issue number1
DOIs
StatePublished - Jun 1979

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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