@article{27a58f130af042d5a879caf28ffae232,
title = "Course of renal pathology in patients with systemic lupus erythematosus",
abstract = "Evaluation of the course of lupus nephropathy by serial kidney biopsy in 50 patients revealed a complex pattern of transitions from one histologic class to another. A high rate of transformations (56 percent) was observed, with fewer than half the patients remaining in the original category. Although the general trend was towards transformation to a less severe lesion (WHO classes III and IV transforming into classes II and V), this was certainly not the rule for all individual classes. These transformations were rarely predictable on the basis of available clinical, laboratory, or pathologic information, and were less common in younger patients. These results help clarify the pathologic behavior of lupus nephropathy in the modern therapeutic era and highlight the value of pathologic examination for the planning and evaluation of therapy in selected patients.",
author = "Lee, {Hyun Soon} and Mujais, {Salim K.} and Kasinath, {Balakuntalam S.} and Spargo, {Benjamin H.} and Katz, {Adrian I.}",
note = "Funding Information: From the Departments of Pathology and Medicine, Universityo f ChicagoR ltzker Schoolo f Medicine, Chicago,I llinois.D r. Lee is the recipient of International Research Fellowship FO5-W/O-3258-OI-SI from the Fogarty International Center, National Institutes of Health. Dr. Kasinath was a fellow of the &tional Kidney Foundation. Dr. Spargo Is the recipient of Research Career Award K6-HL-4418 from the National Heart, Lung, and Blood Institute. Requests for reprints should be addressed to Dr. Adrian I. Katz, University of Chicago, Department of Medicine, Box 453, 5841 South hjaryland Avenue, Chicago, Illinois 60637. Manuscript accepted March 26, 1984. l Current address: Division of Nephrology, University of Illinois. College of Medicine, Chicago, Illinois. t Current address: Section of Nephrology, Rush-Presbyterian St. Luke Medical Center, Chicago, Illinois.",
year = "1984",
month = oct,
doi = "10.1016/0002-9343(84)90350-4",
language = "English (US)",
volume = "77",
pages = "612--620",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "4",
}