Cosupplementation with vitamin E and coenzyme Q10 reduces circulating markers of inflammation in baboons

Li Wang Xing, David L. Rainwater, Michael C. Mahaney, Roland Stocker

    Research output: Contribution to journalArticlepeer-review

    59 Scopus citations


    Background: Inflammation and oxidative stress are processes that mark early metabolic abnormalities in vascular diseases. Objectives: We explored the effects of a high-fat, high-cholesterol (HFHC) diet on vascular responses in baboons and the potential response-attenuating effects of vitamin E and coenzyme Q10 (CoQ10) supplementation. Design: We used a longitudinal design by subjecting 21 baboons (Papio hamadryas) to sequential dietary challenges. Results: After being maintained for 3 mo on a baseline diet (low in fat and cholesterol), 21 baboons were challenged with an HFHC diet for 7 wk. The serum C-reactive protein (CRP) concentrations did not change. Subsequent supplementation of the HFHC diet with the antioxidant vitamin E (250,500, or 1000 IU/kg diet) for 2 wk reduced serum CRP concentrations from 0.91 ± 0.02 to 0.43 ± 0.06 mg/dL. Additional supplementation with CoQ10 (2 g/kg diet) further reduced serum CRP to ≈30% of baseline (0.28 ± 0.03 mg/dL; P = 0.036 compared with the HFHC diet). Introduction of the HFHC diet itself significantly decreased serum P-selectin (from 48.8 ± 7.2 to 32.9 ± 3.7 ng/dL, P = 0.02) and von Willebrand factor (from 187.0 ± 10.1 to 161.9 ± 9.0%, P = 0.02) concentrations. However, neither vitamin E alone nor vitamin E plus CoQ10 significantly altered the serum concentrations of P-selectin or von Willebrand factor. Conclusions: Dietary supplementation with vitamin E alone reduces the baseline inflammatory status that is indicated by the CRP concentration in healthy adult baboons. Cosupplementation with CoQ10, however, significantly enhances this antiinflammatory effect of vitamin E.

    Original languageEnglish (US)
    Pages (from-to)649-655
    Number of pages7
    JournalAmerican Journal of Clinical Nutrition
    Issue number3
    StatePublished - Sep 2004


    • Antioxidants
    • Atherosclerosis
    • Cytokines
    • Endothelial function
    • Oxygen radicals

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Nutrition and Dietetics

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