TY - JOUR
T1 - Cortisol secretion in adolescents with major depressive disorder
AU - Dahl, R.
AU - Puig‐Antich, J.
AU - Ryan, N.
AU - Nelson, B.
AU - Novacenko, H.
AU - Twomey, J.
AU - Williamson, D.
AU - Goetz, R.
AU - Ambrosini, P. J.
PY - 1989/7
Y1 - 1989/7
N2 - Plasma cortisol concentrations were determined every 20 min for 24 h, in a nonstressful environment, among 48 rigorously assessed, mostly outpatient, drug‐free adolescent subjects during an episode of major depression (MDD) and among 40 normal adolescent subjects. There were no significant differences in the 24‐h mean, peak, or nadir, or the time of the nocturnal rise, in plasma cortisol in the 2 groups. Analyses of different subgroups of MDD adolescents according to suicidality, severity of depression, separation anxiety, psychotic subtype, endogenicity, duration of episode, and sex also revealed no significant group differences. Only one adolescent (with MDD) was identified clearly as a hypersecretor of cortisol. These results indicate that abnormalities of spontaneous cortisol secretion are an unusual finding among adolescents with major depression when studied in a nonstressful environment.
AB - Plasma cortisol concentrations were determined every 20 min for 24 h, in a nonstressful environment, among 48 rigorously assessed, mostly outpatient, drug‐free adolescent subjects during an episode of major depression (MDD) and among 40 normal adolescent subjects. There were no significant differences in the 24‐h mean, peak, or nadir, or the time of the nocturnal rise, in plasma cortisol in the 2 groups. Analyses of different subgroups of MDD adolescents according to suicidality, severity of depression, separation anxiety, psychotic subtype, endogenicity, duration of episode, and sex also revealed no significant group differences. Only one adolescent (with MDD) was identified clearly as a hypersecretor of cortisol. These results indicate that abnormalities of spontaneous cortisol secretion are an unusual finding among adolescents with major depression when studied in a nonstressful environment.
KW - adolescence
KW - cortisol
KW - depression
KW - stress
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U2 - 10.1111/j.1600-0447.1989.tb01295.x
DO - 10.1111/j.1600-0447.1989.tb01295.x
M3 - Article
C2 - 2763857
AN - SCOPUS:0024411536
VL - 80
SP - 18
EP - 26
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 1
ER -