Corticotropin-releasing factor (CRF) produces analgesia in humans and rats

Kenneth M Hargreaves, Gregory P. Mueller, Ronald Dubner, David Goldstein, Raymond A. Dionne

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

The analgesic activity of corticotropin releasing factor (CRF) was determined in a clinical model and in the rat hot plate test. Patients administered CRF reported significantly less postoperative pain than patients pretreated with placebo. In rats, injection of CRF resulted in a significant analgesia which was comparable in both intensity and duration to a 300 times greater molar dose of morphine. These findings suggest that endogenous CRF may play a physiologic role in modulating pain when released under conditions of stress.

Original languageEnglish (US)
Pages (from-to)154-157
Number of pages4
JournalBrain Research
Volume422
Issue number1
DOIs
StatePublished - Sep 29 1987
Externally publishedYes

Fingerprint

Corticotropin-Releasing Hormone
Analgesia
Postoperative Pain
Morphine
Analgesics
Placebos
Pain
Injections

Keywords

  • Analgesia
  • Corticotropin releasing factor
  • β-Endorphin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Corticotropin-releasing factor (CRF) produces analgesia in humans and rats. / Hargreaves, Kenneth M; Mueller, Gregory P.; Dubner, Ronald; Goldstein, David; Dionne, Raymond A.

In: Brain Research, Vol. 422, No. 1, 29.09.1987, p. 154-157.

Research output: Contribution to journalArticle

Hargreaves, Kenneth M ; Mueller, Gregory P. ; Dubner, Ronald ; Goldstein, David ; Dionne, Raymond A. / Corticotropin-releasing factor (CRF) produces analgesia in humans and rats. In: Brain Research. 1987 ; Vol. 422, No. 1. pp. 154-157.
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