Corticotropin-releasing factor (CRF) produces analgesia in humans and rats

Kenneth M. Hargreaves, Gregory P. Mueller, Ronald Dubner, David Goldstein, Raymond A. Dionne

Research output: Contribution to journalArticlepeer-review

85 Scopus citations


The analgesic activity of corticotropin releasing factor (CRF) was determined in a clinical model and in the rat hot plate test. Patients administered CRF reported significantly less postoperative pain than patients pretreated with placebo. In rats, injection of CRF resulted in a significant analgesia which was comparable in both intensity and duration to a 300 times greater molar dose of morphine. These findings suggest that endogenous CRF may play a physiologic role in modulating pain when released under conditions of stress.

Original languageEnglish (US)
Pages (from-to)154-157
Number of pages4
JournalBrain Research
Issue number1
StatePublished - Sep 29 1987
Externally publishedYes


  • Analgesia
  • Corticotropin releasing factor
  • β-Endorphin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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