Corticotropin-releasing factor (CRF) produces analgesia in humans and rats

Kenneth M. Hargreaves; Gregory P. Mueller; Ronald Dubner; David Goldstein; Raymond A. Dionne

doi:10.1016/0006-8993(87)90550-6

Corticotropin-releasing factor (CRF) produces analgesia in humans and rats

Kenneth M. Hargreaves, Gregory P. Mueller, Ronald Dubner, David Goldstein, Raymond A. Dionne

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

The analgesic activity of corticotropin releasing factor (CRF) was determined in a clinical model and in the rat hot plate test. Patients administered CRF reported significantly less postoperative pain than patients pretreated with placebo. In rats, injection of CRF resulted in a significant analgesia which was comparable in both intensity and duration to a 300 times greater molar dose of morphine. These findings suggest that endogenous CRF may play a physiologic role in modulating pain when released under conditions of stress.

Original language	English (US)
Pages (from-to)	154-157
Number of pages	4
Journal	Brain Research
Volume	422
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(87)90550-6
State	Published - Sep 29 1987
Externally published	Yes

Keywords

Analgesia
Corticotropin releasing factor
β-Endorphin

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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10.1016/0006-8993(87)90550-6

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AU - Dionne, Raymond A.

PY - 1987/9/29

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AB - The analgesic activity of corticotropin releasing factor (CRF) was determined in a clinical model and in the rat hot plate test. Patients administered CRF reported significantly less postoperative pain than patients pretreated with placebo. In rats, injection of CRF resulted in a significant analgesia which was comparable in both intensity and duration to a 300 times greater molar dose of morphine. These findings suggest that endogenous CRF may play a physiologic role in modulating pain when released under conditions of stress.

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KW - β-Endorphin

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Corticotropin-releasing factor (CRF) produces analgesia in humans and rats

Abstract

Keywords

ASJC Scopus subject areas

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