TY - JOUR
T1 - Corticotropin releasing factor (CRF) has a peripheral site of action for antinociception
AU - Hargreaves, Kenneth M.
AU - Dubner, Ronald
AU - Costello, Ann H.
PY - 1989/11/7
Y1 - 1989/11/7
N2 - In the rat carrageenan model of inflammation, systemically administered CRF significantly reduced hyperalgesia, edema and hyperthermia. While hypophysectomy had no effect, adrenalectomy blocked the effects of systemic CRF on edema and hyperthermia, and tended to reduce the peptide's ability to suppress hyperalgesia. When CRF was injected into one of two bilaterally inflamed hindpaws, it significantly inhibited hyperalgesia via a peripheral mechanism. In this model of inflammation, the antinociceptive effects of CRF are peripherally mediated, while the anti-inflammatory effects are dependent on the adrenal gland.
AB - In the rat carrageenan model of inflammation, systemically administered CRF significantly reduced hyperalgesia, edema and hyperthermia. While hypophysectomy had no effect, adrenalectomy blocked the effects of systemic CRF on edema and hyperthermia, and tended to reduce the peptide's ability to suppress hyperalgesia. When CRF was injected into one of two bilaterally inflamed hindpaws, it significantly inhibited hyperalgesia via a peripheral mechanism. In this model of inflammation, the antinociceptive effects of CRF are peripherally mediated, while the anti-inflammatory effects are dependent on the adrenal gland.
KW - Analgesia
KW - Corticotropin releasing factor (CRF)
KW - Hyperalgesia
KW - Inflammation
KW - Pain
UR - http://www.scopus.com/inward/record.url?scp=0024317308&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024317308&partnerID=8YFLogxK
U2 - 10.1016/0014-2999(89)90550-5
DO - 10.1016/0014-2999(89)90550-5
M3 - Article
C2 - 2620699
AN - SCOPUS:0024317308
VL - 170
SP - 275
EP - 279
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3
ER -