Corticosteroid potentiation of surfactant dose response in preterm rabbits

S. Seidner, A. Pettenazzo, M. Ikegami, A. Jobe

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Fetal rabbits were treated with corticosteroids by maternal administration for 48 h before delivery at 27 days gestational age. Both corticosteroid-treated and control animals then received exogenous natural rabbit surfactant at birth at doses of 0-75 mg lipid/kg. After 10 min of ventilation at tidal volumes of 12-15 ml/kg, static pressure-volume measurements were made. At all surfactant doses there was a significantly higher maximal lung volume, higher dynamic compliance, and lower pressure requirement in the corticosteroid-treated than in the control rabbits (P < 0.01). Control animals showed incremental improvements in dynamic compliances and maximal lung volumes up to a dose of 50 mg/kg, whereas corticosteroid treated animals improved to a maximum at the low dose of 15 mg/kg (P < 0.01). However, surface tension as assessed by lung stability index improved with increasing surfactant dose but was not significantly different between corticosteroid-treated and control animals at a given dose. The results imply that maternal corticosteroid treatment potentiates surfactant replacement by a change in lung structure that is independent of surface tension effects.

Original languageEnglish (US)
Pages (from-to)2366-2371
Number of pages6
JournalJournal of applied physiology
Issue number6
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


Dive into the research topics of 'Corticosteroid potentiation of surfactant dose response in preterm rabbits'. Together they form a unique fingerprint.

Cite this