Corticosteroid potentiation of surfactant dose response in preterm rabbits

Steven R Seidner, A. Pettenazzo, M. Ikegami, A. Jobe

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Fetal rabbits were treated with corticosteroids by maternal administration for 48 h before delivery at 27 days gestational age. Both corticosteroid-treated and control animals then received exogenous natural rabbit surfactant at birth at doses of 0-75 mg lipid/kg. After 10 min of ventilation at tidal volumes of 12-15 ml/kg, static pressure-volume measurements were made. At all surfactant doses there was a significantly higher maximal lung volume, higher dynamic compliance, and lower pressure requirement in the corticosteroid-treated than in the control rabbits (P < 0.01). Control animals showed incremental improvements in dynamic compliances and maximal lung volumes up to a dose of 50 mg/kg, whereas corticosteroid treated animals improved to a maximum at the low dose of 15 mg/kg (P < 0.01). However, surface tension as assessed by lung stability index improved with increasing surfactant dose but was not significantly different between corticosteroid-treated and control animals at a given dose. The results imply that maternal corticosteroid treatment potentiates surfactant replacement by a change in lung structure that is independent of surface tension effects.

Original languageEnglish (US)
Pages (from-to)2366-2371
Number of pages6
JournalJournal of Applied Physiology
Volume64
Issue number6
StatePublished - 1988
Externally publishedYes

Fingerprint

Surface-Active Agents
Adrenal Cortex Hormones
Rabbits
Surface Tension
Lung
Mothers
Lung Compliance
Pressure
Tidal Volume
Gestational Age
Compliance
Ventilation
Parturition
Lipids

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Seidner, S. R., Pettenazzo, A., Ikegami, M., & Jobe, A. (1988). Corticosteroid potentiation of surfactant dose response in preterm rabbits. Journal of Applied Physiology, 64(6), 2366-2371.

Corticosteroid potentiation of surfactant dose response in preterm rabbits. / Seidner, Steven R; Pettenazzo, A.; Ikegami, M.; Jobe, A.

In: Journal of Applied Physiology, Vol. 64, No. 6, 1988, p. 2366-2371.

Research output: Contribution to journalArticle

Seidner, SR, Pettenazzo, A, Ikegami, M & Jobe, A 1988, 'Corticosteroid potentiation of surfactant dose response in preterm rabbits', Journal of Applied Physiology, vol. 64, no. 6, pp. 2366-2371.
Seidner SR, Pettenazzo A, Ikegami M, Jobe A. Corticosteroid potentiation of surfactant dose response in preterm rabbits. Journal of Applied Physiology. 1988;64(6):2366-2371.
Seidner, Steven R ; Pettenazzo, A. ; Ikegami, M. ; Jobe, A. / Corticosteroid potentiation of surfactant dose response in preterm rabbits. In: Journal of Applied Physiology. 1988 ; Vol. 64, No. 6. pp. 2366-2371.
@article{b0a364f178724f2689db1ce54d0f5b76,
title = "Corticosteroid potentiation of surfactant dose response in preterm rabbits",
abstract = "Fetal rabbits were treated with corticosteroids by maternal administration for 48 h before delivery at 27 days gestational age. Both corticosteroid-treated and control animals then received exogenous natural rabbit surfactant at birth at doses of 0-75 mg lipid/kg. After 10 min of ventilation at tidal volumes of 12-15 ml/kg, static pressure-volume measurements were made. At all surfactant doses there was a significantly higher maximal lung volume, higher dynamic compliance, and lower pressure requirement in the corticosteroid-treated than in the control rabbits (P < 0.01). Control animals showed incremental improvements in dynamic compliances and maximal lung volumes up to a dose of 50 mg/kg, whereas corticosteroid treated animals improved to a maximum at the low dose of 15 mg/kg (P < 0.01). However, surface tension as assessed by lung stability index improved with increasing surfactant dose but was not significantly different between corticosteroid-treated and control animals at a given dose. The results imply that maternal corticosteroid treatment potentiates surfactant replacement by a change in lung structure that is independent of surface tension effects.",
author = "Seidner, {Steven R} and A. Pettenazzo and M. Ikegami and A. Jobe",
year = "1988",
language = "English (US)",
volume = "64",
pages = "2366--2371",
journal = "Journal of Applied Physiology",
issn = "0161-7567",
publisher = "American Physiological Society",
number = "6",

}

TY - JOUR

T1 - Corticosteroid potentiation of surfactant dose response in preterm rabbits

AU - Seidner, Steven R

AU - Pettenazzo, A.

AU - Ikegami, M.

AU - Jobe, A.

PY - 1988

Y1 - 1988

N2 - Fetal rabbits were treated with corticosteroids by maternal administration for 48 h before delivery at 27 days gestational age. Both corticosteroid-treated and control animals then received exogenous natural rabbit surfactant at birth at doses of 0-75 mg lipid/kg. After 10 min of ventilation at tidal volumes of 12-15 ml/kg, static pressure-volume measurements were made. At all surfactant doses there was a significantly higher maximal lung volume, higher dynamic compliance, and lower pressure requirement in the corticosteroid-treated than in the control rabbits (P < 0.01). Control animals showed incremental improvements in dynamic compliances and maximal lung volumes up to a dose of 50 mg/kg, whereas corticosteroid treated animals improved to a maximum at the low dose of 15 mg/kg (P < 0.01). However, surface tension as assessed by lung stability index improved with increasing surfactant dose but was not significantly different between corticosteroid-treated and control animals at a given dose. The results imply that maternal corticosteroid treatment potentiates surfactant replacement by a change in lung structure that is independent of surface tension effects.

AB - Fetal rabbits were treated with corticosteroids by maternal administration for 48 h before delivery at 27 days gestational age. Both corticosteroid-treated and control animals then received exogenous natural rabbit surfactant at birth at doses of 0-75 mg lipid/kg. After 10 min of ventilation at tidal volumes of 12-15 ml/kg, static pressure-volume measurements were made. At all surfactant doses there was a significantly higher maximal lung volume, higher dynamic compliance, and lower pressure requirement in the corticosteroid-treated than in the control rabbits (P < 0.01). Control animals showed incremental improvements in dynamic compliances and maximal lung volumes up to a dose of 50 mg/kg, whereas corticosteroid treated animals improved to a maximum at the low dose of 15 mg/kg (P < 0.01). However, surface tension as assessed by lung stability index improved with increasing surfactant dose but was not significantly different between corticosteroid-treated and control animals at a given dose. The results imply that maternal corticosteroid treatment potentiates surfactant replacement by a change in lung structure that is independent of surface tension effects.

UR - http://www.scopus.com/inward/record.url?scp=0023909262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023909262&partnerID=8YFLogxK

M3 - Article

C2 - 3403420

AN - SCOPUS:0023909262

VL - 64

SP - 2366

EP - 2371

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 6

ER -