Corticosteroid potentiation of surfactant dose response in preterm rabbits

S. Seidner, A. Pettenazzo, M. Ikegami, A. Jobe

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Abstract

Fetal rabbits were treated with corticosteroids by maternal administration for 48 h before delivery at 27 days gestational age. Both corticosteroid-treated and control animals then received exogenous natural rabbit surfactant at birth at doses of 0-75 mg lipid/kg. After 10 min of ventilation at tidal volumes of 12-15 ml/kg, static pressure-volume measurements were made. At all surfactant doses there was a significantly higher maximal lung volume, higher dynamic compliance, and lower pressure requirement in the corticosteroid-treated than in the control rabbits (P < 0.01). Control animals showed incremental improvements in dynamic compliances and maximal lung volumes up to a dose of 50 mg/kg, whereas corticosteroid treated animals improved to a maximum at the low dose of 15 mg/kg (P < 0.01). However, surface tension as assessed by lung stability index improved with increasing surfactant dose but was not significantly different between corticosteroid-treated and control animals at a given dose. The results imply that maternal corticosteroid treatment potentiates surfactant replacement by a change in lung structure that is independent of surface tension effects.

Original languageEnglish (US)
Pages (from-to)2366-2371
Number of pages6
JournalJournal of applied physiology
Volume64
Issue number6
Publication statusPublished - Jan 1 1988

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Corticosteroid potentiation of surfactant dose response in preterm rabbits. / Seidner, S.; Pettenazzo, A.; Ikegami, M.; Jobe, A.

In: Journal of applied physiology, Vol. 64, No. 6, 01.01.1988, p. 2366-2371.

Research output: Contribution to journalArticle