Cortical sulci and bipolar disorder

Thomas R. Coyle; Peter Kochunov; Rupal D. Patel; Fabiano G. Nery; Jack L Lancaster; Jean François Mangin; Denis Rivière; David R. Pillow; Gregory J. Davis; Mark A. Nicoletti; E. Serap Monkul; Peter T. Fox; Jair C. Soares

doi:10.1097/01.wnr.0000239957.53072.f0

Cortical sulci and bipolar disorder

Thomas R. Coyle, Peter Kochunov, Rupal D. Patel, Fabiano G. Nery, Jack L Lancaster, Jean François Mangin, Denis Rivière, David R. Pillow, Gregory J. Davis, Mark A. Nicoletti, E. Serap Monkul, Peter T. Fox, Jair C. Soares

Department of Radiology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

The width of cortical sulci in bipolar patients (n=19) and healthy controls (n=35) was examined using a novel automated technique involving magnetic resonance imaging. All sulci were wider for bipolar patients than for healthy controls. Bipolar-control differences were largest for the superior and intermediate frontal sulci, smallest for the occipital and cingulate sulci, and intermediate in magnitude for the other sulci (intraparietal, inferior frontal, and central sulci). The results were interpreted in terms of neurodegenerative-illness-related processes, which could produce cortical atrophy and result in wider sulci.

Original language	English (US)
Pages (from-to)	1739-1742
Number of pages	4
Journal	NeuroReport
Volume	17
Issue number	16
DOIs	https://doi.org/10.1097/01.wnr.0000239957.53072.f0
State	Published - Nov 2006

Keywords

Bipolar disorder
Brain
Cortical sulci
Diagnostic imaging
Magnetic resonance imaging
Sulcal width

ASJC Scopus subject areas

General Neuroscience

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10.1097/01.wnr.0000239957.53072.f0

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title = "Cortical sulci and bipolar disorder",

abstract = "The width of cortical sulci in bipolar patients (n=19) and healthy controls (n=35) was examined using a novel automated technique involving magnetic resonance imaging. All sulci were wider for bipolar patients than for healthy controls. Bipolar-control differences were largest for the superior and intermediate frontal sulci, smallest for the occipital and cingulate sulci, and intermediate in magnitude for the other sulci (intraparietal, inferior frontal, and central sulci). The results were interpreted in terms of neurodegenerative-illness-related processes, which could produce cortical atrophy and result in wider sulci.",

keywords = "Bipolar disorder, Brain, Cortical sulci, Diagnostic imaging, Magnetic resonance imaging, Sulcal width",

author = "Coyle, {Thomas R.} and Peter Kochunov and Patel, {Rupal D.} and Nery, {Fabiano G.} and Lancaster, {Jack L} and Mangin, {Jean Fran{\c c}ois} and Denis Rivi{\`e}re and Pillow, {David R.} and Davis, {Gregory J.} and Nicoletti, {Mark A.} and {Serap Monkul}, E. and Fox, {Peter T.} and Soares, {Jair C.}",

year = "2006",

month = nov,

doi = "10.1097/01.wnr.0000239957.53072.f0",

language = "English (US)",

volume = "17",

pages = "1739--1742",

journal = "NeuroReport",

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T1 - Cortical sulci and bipolar disorder

AU - Coyle, Thomas R.

AU - Kochunov, Peter

AU - Patel, Rupal D.

AU - Nery, Fabiano G.

AU - Lancaster, Jack L

AU - Mangin, Jean François

AU - Rivière, Denis

AU - Pillow, David R.

AU - Davis, Gregory J.

AU - Nicoletti, Mark A.

AU - Serap Monkul, E.

AU - Fox, Peter T.

AU - Soares, Jair C.

PY - 2006/11

Y1 - 2006/11

N2 - The width of cortical sulci in bipolar patients (n=19) and healthy controls (n=35) was examined using a novel automated technique involving magnetic resonance imaging. All sulci were wider for bipolar patients than for healthy controls. Bipolar-control differences were largest for the superior and intermediate frontal sulci, smallest for the occipital and cingulate sulci, and intermediate in magnitude for the other sulci (intraparietal, inferior frontal, and central sulci). The results were interpreted in terms of neurodegenerative-illness-related processes, which could produce cortical atrophy and result in wider sulci.

AB - The width of cortical sulci in bipolar patients (n=19) and healthy controls (n=35) was examined using a novel automated technique involving magnetic resonance imaging. All sulci were wider for bipolar patients than for healthy controls. Bipolar-control differences were largest for the superior and intermediate frontal sulci, smallest for the occipital and cingulate sulci, and intermediate in magnitude for the other sulci (intraparietal, inferior frontal, and central sulci). The results were interpreted in terms of neurodegenerative-illness-related processes, which could produce cortical atrophy and result in wider sulci.

KW - Bipolar disorder

KW - Brain

KW - Cortical sulci

KW - Diagnostic imaging

KW - Magnetic resonance imaging

KW - Sulcal width

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Cortical sulci and bipolar disorder

Abstract

Keywords

ASJC Scopus subject areas

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