Cortical sulci and bipolar disorder

Thomas R. Coyle, Peter Kochunov, Rupal D. Patel, Fabiano G. Nery, Jack L Lancaster, Jean François Mangin, Denis Rivière, David R. Pillow, Gregory J. Davis, Mark A. Nicoletti, E. Serap Monkul, Peter T. Fox, Jair C. Soares

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The width of cortical sulci in bipolar patients (n=19) and healthy controls (n=35) was examined using a novel automated technique involving magnetic resonance imaging. All sulci were wider for bipolar patients than for healthy controls. Bipolar-control differences were largest for the superior and intermediate frontal sulci, smallest for the occipital and cingulate sulci, and intermediate in magnitude for the other sulci (intraparietal, inferior frontal, and central sulci). The results were interpreted in terms of neurodegenerative-illness-related processes, which could produce cortical atrophy and result in wider sulci.

Original languageEnglish (US)
Pages (from-to)1739-1742
Number of pages4
Issue number16
StatePublished - Nov 2006


  • Bipolar disorder
  • Brain
  • Cortical sulci
  • Diagnostic imaging
  • Magnetic resonance imaging
  • Sulcal width

ASJC Scopus subject areas

  • General Neuroscience


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