Correspondent functional topography of the human left inferior parietal lobule at rest and under task revealed using resting-state fMRI and coactivation based parcellation

Jiaojian Wang, Sangma Xie, Xin Guo, Benjamin Becker, Peter T Fox, Simon B. Eickhoff, Tianzi Jiang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The human left inferior parietal lobule (LIPL) plays a pivotal role in many cognitive functions and is an important node in the default mode network (DMN). Although many previous studies have proposed different parcellation schemes for the LIPL, the detailed functional organization of the LIPL and the exact correspondence between the DMN and LIPL subregions remain unclear. Mounting evidence indicates that spontaneous fluctuations in the brain are strongly associated with cognitive performance at the behavioral level. However, whether a consistent functional topographic organization of the LIPL during rest and under task can be revealed remains unknown. Here, they used resting-state functional connectivity (RSFC) and task-related coactivation patterns separately to parcellate the LIPL and identified seven subregions. Four subregions were located in the supramarginal gyrus (SMG) and three subregions were located in the angular gyrus (AG). The subregion-specific networks and functional characterization revealed that the four anterior subregions were found to be primarily involved in sensorimotor processing, movement imagination and inhibitory control, audition perception and speech processing, and social cognition, whereas the three posterior subregions were mainly involved in episodic memory, semantic processing, and spatial cognition. The results revealed a detailed functional organization of the LIPL and suggested that the LIPL is a functionally heterogeneous area. In addition, the present study demonstrated that the functional architecture of the LIPL during rest corresponds with that found in task processing.

Original languageEnglish (US)
JournalHuman Brain Mapping
DOIs
StateAccepted/In press - 2016

Fingerprint

Parietal Lobe
Magnetic Resonance Imaging
Cognition
Social Perception
Imagination
Speech Perception
Episodic Memory
Semantics
Hearing

Keywords

  • Coactivation
  • Correspondent functional topography
  • Left inferior parietal lobule
  • Parcellation
  • Resting-state

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Correspondent functional topography of the human left inferior parietal lobule at rest and under task revealed using resting-state fMRI and coactivation based parcellation. / Wang, Jiaojian; Xie, Sangma; Guo, Xin; Becker, Benjamin; Fox, Peter T; Eickhoff, Simon B.; Jiang, Tianzi.

In: Human Brain Mapping, 2016.

Research output: Contribution to journalArticle

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