Correlations between uptake of technetium, calcium, phosphate, and mineralization in rat tibial bone repair

J. Shani, D. Amir, W. A. Soskolne, Z. Schwartz, R. Chisin, J. Sela

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Abstract

Technetium-99m-(99mTc) phosphates are extensively used for detection of bone formation and resorption. The present is a study of 99mTc incorporation during bone remodeling. Uptake of 99mTc-labeled phosphate was studied in an animal model of primary osteogenesis following tibial marrow injury and incorporation was correlated to that of calcium-47 (47Ca), phosphorus-32 (32P), and with matrix vesicle calcification. Isotope uptake on Day 6 in the whole bone was increased compared to controls. On this day, an increase in vesicular diameter and distance from the calcified front was previously observed. Technetium-99m-labeled phosphates were detected only in the organic phase. Phosphorus-32 and 47Ca were detected in both organic and inorganic phases. It is suggested that 99mTc serves as a specific marker to the anabolic phase of remodeling. Increased incorporation of 99mTc during bone healing indicates enhanced organic matrix formation and not calcification.

Original languageEnglish (US)
Pages (from-to)2011-2014
Number of pages4
JournalJournal of Nuclear Medicine
Volume31
Issue number12
Publication statusPublished - Dec 1 1990

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Shani, J., Amir, D., Soskolne, W. A., Schwartz, Z., Chisin, R., & Sela, J. (1990). Correlations between uptake of technetium, calcium, phosphate, and mineralization in rat tibial bone repair. Journal of Nuclear Medicine, 31(12), 2011-2014.