Correlations between uptake of technetium, calcium, phosphate, and mineralization in rat tibial bone repair

J. Shani, D. Amir, W. A. Soskolne, Z. Schwartz, R. Chisin, J. Sela

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Technetium-99m-(99mTc) phosphates are extensively used for detection of bone formation and resorption. The present is a study of 99mTc incorporation during bone remodeling. Uptake of 99mTc-labeled phosphate was studied in an animal model of primary osteogenesis following tibial marrow injury and incorporation was correlated to that of calcium-47 (47Ca), phosphorus-32 (32P), and with matrix vesicle calcification. Isotope uptake on Day 6 in the whole bone was increased compared to controls. On this day, an increase in vesicular diameter and distance from the calcified front was previously observed. Technetium-99m-labeled phosphates were detected only in the organic phase. Phosphorus-32 and 47Ca were detected in both organic and inorganic phases. It is suggested that 99mTc serves as a specific marker to the anabolic phase of remodeling. Increased incorporation of 99mTc during bone healing indicates enhanced organic matrix formation and not calcification.

Original languageEnglish (US)
Pages (from-to)2011-2014
Number of pages4
JournalJournal of Nuclear Medicine
Volume31
Issue number12
StatePublished - Dec 1 1990

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Correlations between uptake of technetium, calcium, phosphate, and mineralization in rat tibial bone repair'. Together they form a unique fingerprint.

Cite this