TY - JOUR
T1 - Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis
AU - Hiehle, John F.
AU - Lenkinski, Robert E.
AU - Grossman, Robert I.
AU - Dousset, Vincent
AU - Ramer, Karen N.
AU - Schnall, Mitchell D.
AU - Cohen, Jeffrey A.
AU - Gonzalez‐Scarano, Francisco
PY - 1994/9
Y1 - 1994/9
N2 - Magnetization transfer imaging (MT) and localized proton spectroscopy (1H‐MRS) were utilized in the evaluation of lesioins (high signal abnormalities on T2‐weighted images) and normal‐appearing white matter (NAWM) in multiple sclerosis (MI). Eleven patients with a clinical diagnosis of MS were independently evaluated with both 1H‐MRS and MT. The magnetization transfer ratio (MTR) of lesions was compared with the relative concentration of Kacetyl‐aspartate (NAA) and a composite peak at 2.1 to 2.6 ppm termed “marker peaks”. The MTR of white matter lesions in the MS patients was markedly decreased (6–34%; normal ≈42%), and correlated well with increase in the marker peaks region (0.94–3.89). There was no correlation between the relative concentration of NAA and MTR. Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination.
AB - Magnetization transfer imaging (MT) and localized proton spectroscopy (1H‐MRS) were utilized in the evaluation of lesioins (high signal abnormalities on T2‐weighted images) and normal‐appearing white matter (NAWM) in multiple sclerosis (MI). Eleven patients with a clinical diagnosis of MS were independently evaluated with both 1H‐MRS and MT. The magnetization transfer ratio (MTR) of lesions was compared with the relative concentration of Kacetyl‐aspartate (NAA) and a composite peak at 2.1 to 2.6 ppm termed “marker peaks”. The MTR of white matter lesions in the MS patients was markedly decreased (6–34%; normal ≈42%), and correlated well with increase in the marker peaks region (0.94–3.89). There was no correlation between the relative concentration of NAA and MTR. Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination.
KW - magnetic resonance (MR)
KW - magnetization transfer contrast
KW - multiple sclerosis
KW - proton spectroscopy (H‐MRS)
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U2 - 10.1002/mrm.1910320303
DO - 10.1002/mrm.1910320303
M3 - Article
C2 - 7984060
AN - SCOPUS:0027981674
VL - 32
SP - 285
EP - 293
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 3
ER -