Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis

John F. Hiehle; Robert E. Lenkinski; Robert I. Grossman; Vincent Dousset; Karen N. Ramer; Mitchell D. Schnall; Jeffrey A. Cohen; Francisco Gonzalez‐Scarano

doi:10.1002/mrm.1910320303

Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis

John F. Hiehle, Robert E. Lenkinski, Robert I. Grossman, Vincent Dousset, Karen N. Ramer, Mitchell D. Schnall, Jeffrey A. Cohen, Francisco Gonzalez‐Scarano

Neurology

Research output: Contribution to journal › Article › peer-review

103 Scopus citations

Abstract

Magnetization transfer imaging (MT) and localized proton spectroscopy (¹H‐MRS) were utilized in the evaluation of lesioins (high signal abnormalities on T₂‐weighted images) and normal‐appearing white matter (NAWM) in multiple sclerosis (MI). Eleven patients with a clinical diagnosis of MS were independently evaluated with both ¹H‐MRS and MT. The magnetization transfer ratio (MTR) of lesions was compared with the relative concentration of Kacetyl‐aspartate (NAA) and a composite peak at 2.1 to 2.6 ppm termed “marker peaks”. The MTR of white matter lesions in the MS patients was markedly decreased (6–34%; normal ≈42%), and correlated well with increase in the marker peaks region (0.94–3.89). There was no correlation between the relative concentration of NAA and MTR. Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination.

Original language	English (US)
Pages (from-to)	285-293
Number of pages	9
Journal	Magnetic Resonance in Medicine
Volume	32
Issue number	3
DOIs	https://doi.org/10.1002/mrm.1910320303
State	Published - Sep 1994

Keywords

magnetic resonance (MR)
magnetization transfer contrast
multiple sclerosis
proton spectroscopy (H‐MRS)

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1002/mrm.1910320303

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Hiehle, J. F., Lenkinski, R. E., Grossman, R. I., Dousset, V., Ramer, K. N., Schnall, M. D., Cohen, J. A., & Gonzalez‐Scarano, F. (1994). Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis. Magnetic Resonance in Medicine, 32(3), 285-293. https://doi.org/10.1002/mrm.1910320303

Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis. / Hiehle, John F.; Lenkinski, Robert E.; Grossman, Robert I.; Dousset, Vincent; Ramer, Karen N.; Schnall, Mitchell D.; Cohen, Jeffrey A.; Gonzalez‐Scarano, Francisco.

In: Magnetic Resonance in Medicine, Vol. 32, No. 3, 09.1994, p. 285-293.

Research output: Contribution to journal › Article › peer-review

Hiehle, JF, Lenkinski, RE, Grossman, RI, Dousset, V, Ramer, KN, Schnall, MD, Cohen, JA & Gonzalez‐Scarano, F 1994, 'Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis', Magnetic Resonance in Medicine, vol. 32, no. 3, pp. 285-293. https://doi.org/10.1002/mrm.1910320303

Hiehle, John F. ; Lenkinski, Robert E. ; Grossman, Robert I. ; Dousset, Vincent ; Ramer, Karen N. ; Schnall, Mitchell D. ; Cohen, Jeffrey A. ; Gonzalez‐Scarano, Francisco. / Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis. In: Magnetic Resonance in Medicine. 1994 ; Vol. 32, No. 3. pp. 285-293.

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abstract = "Magnetization transfer imaging (MT) and localized proton spectroscopy (1H‐MRS) were utilized in the evaluation of lesioins (high signal abnormalities on T2‐weighted images) and normal‐appearing white matter (NAWM) in multiple sclerosis (MI). Eleven patients with a clinical diagnosis of MS were independently evaluated with both 1H‐MRS and MT. The magnetization transfer ratio (MTR) of lesions was compared with the relative concentration of Kacetyl‐aspartate (NAA) and a composite peak at 2.1 to 2.6 ppm termed “marker peaks”. The MTR of white matter lesions in the MS patients was markedly decreased (6–34%; normal ≈42%), and correlated well with increase in the marker peaks region (0.94–3.89). There was no correlation between the relative concentration of NAA and MTR. Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination.",

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AB - Magnetization transfer imaging (MT) and localized proton spectroscopy (1H‐MRS) were utilized in the evaluation of lesioins (high signal abnormalities on T2‐weighted images) and normal‐appearing white matter (NAWM) in multiple sclerosis (MI). Eleven patients with a clinical diagnosis of MS were independently evaluated with both 1H‐MRS and MT. The magnetization transfer ratio (MTR) of lesions was compared with the relative concentration of Kacetyl‐aspartate (NAA) and a composite peak at 2.1 to 2.6 ppm termed “marker peaks”. The MTR of white matter lesions in the MS patients was markedly decreased (6–34%; normal ≈42%), and correlated well with increase in the marker peaks region (0.94–3.89). There was no correlation between the relative concentration of NAA and MTR. Increased resonance peaks in the 2.1 to 2.6 ppm range and marked decreases in MTR may be a relatively specific indicators of demyelination.

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Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis

Abstract

Keywords

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