Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst

Derek Denton; Robert Shade; Frank Zamarippa; Gary Egan; John Blair-West; Michael Mckinley; Peter Fox

doi:10.1073/pnas.96.5.2532

Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst

Derek Denton, Robert Shade, Frank Zamarippa, Gary Egan, John Blair-West, Michael Mckinley, Peter Fox

Research Imaging Institute

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Abstract

Positron emission tomography studies were conducted during genesis of moderate thirst by rapid i.v. infusion of hypertonic saline (0.51 M) and after satiation of thirst by drinking water. The correlation of regional cerebral blood flow with the change in the plasma Na concentration showed a significant group of cerebral activations in the anterior cingulate region and also a site in the middle temporal gyrus and in the periaqueductal gray. Strongest deactivations occurred in the parahippocampal and frontal gyri. The data are consistent with an important role of the anterior cingulate in the genesis of thirst.

Original language	English (US)
Pages (from-to)	2532-2537
Number of pages	6
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	96
Issue number	5
DOIs	https://doi.org/10.1073/pnas.96.5.2532
State	Published - Mar 2 1999

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Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst. / Denton, Derek; Shade, Robert; Zamarippa, Frank et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 5, 02.03.1999, p. 2532-2537.

Research output: Contribution to journal › Article › peer-review

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Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst

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