Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection

M. Mar Rodríguez, F. Javier Pastor, Enrique Calvo, Valentina Salas, Deanna A. Sutton, Josep Guarro

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

A broth microdilution method was used to evaluate the in vitro activities of seven antifungal agents against 15 clinical strains of Rhizopus microsporus. Amphotericin B (AMB) and posaconazole (POS) were the most active drugs. In a model of disseminated R. microsporus infection in immunosuppressed mice, we studied the efficacy of POS administered once or twice daily against four of the strains previously tested in vitro and compared it with that of liposomal AMB (LAMB). LAMB was the most effective treatment for the two strains with intermediate susceptibility to POS. For the two POS-susceptible strains, LAMB and POS at 20 mg/kg of body weight twice a day orally showed similar efficacies. The in vivo efficacy of POS administered twice a day orally correlated with the in vitro susceptibility data and the serum drug concentrations.

Original languageEnglish (US)
Pages (from-to)5022-5025
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume53
Issue number12
DOIs
StatePublished - Dec 2009

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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