Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: Improvement with melatonin treatment

Eloisa Gitto, Russel J. Reiter, Giuseppe Sabatino, Giuseppe Buonocore, Carmelo Romeo, Placido Gitto, Concetta Buggé, Giuseppe Trimarchi, Ignazio Barberi

Research output: Contribution to journalArticle

89 Scopus citations


Improved survival because of advances in neonatal care has resulted in an increased number of infants at risk for chronic lung disease. Even though the etiology of lung injury is multifactorial, recent animal and clinical data indicate that pulmonary damage depends in large part on the ventilatory strategies used. Ventilator-associated lung injury was believed to result from the use of high pressure, thus, the term barotraumas. This trauma is believed to involve free-radical damage. Oxidant injury is a serious cause of lung injury. In the present study, 110 newborns with respiratory distress syndrome were studied; 55 were treated with melatonin and the other 55 with placebo. All the subjects were mechanically ventilated with or without guaranteed volume. Proinflammatory cytokines [interleukin (IL)-6, IL-8 and tumor necrosis factor (TNF)-α] were measured in tracheobronchial aspirate and the clinical outcome was evaluated. Melatonin treatment reduced the proinflammatory cytokines and improved the clinical outcome. The beneficial action of melatonin presumably related to its antioxidative actions.

Original languageEnglish (US)
Pages (from-to)287-293
Number of pages7
JournalJournal of pineal research
Issue number3
StatePublished - Oct 1 2005



  • Melatonin
  • Modality of ventilation
  • Newborn
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology

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