Correcting for ascertainment bias in the COGA data set

Anthony G. Comuzzie, Jeff T. Williams

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

The effects of several corrections for ascertainment bias on a linkage result in the COGA data are examined. A correction that models the complete ascertainment protocol markedly reduces the evidence for linkage. Different partial corrections increase the linkage signal and recover good estimates of the population trait prevalence, but do not represent adequately the complexity of the COGA ascertainment scheme. Evidently the present size of the COGA data set cannot support a complete correction for ascertainment bias, but an effective partial correction can and should be implemented.

Original languageEnglish (US)
Pages (from-to)S109-S114
JournalGenetic epidemiology
Volume17
Issue numberSUPPL. 1
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Liability
  • Linkage analysis
  • Sampling
  • Statistical genetics
  • Threshold model

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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