Corpus callosum morphology in capuchin monkeys is influenced by sex and handedness

Kimberley A. Phillips, Chet C. Sherwood, Alayna L. Lilak

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Sex differences have been reported in both overall corpus callosum area and its regional subdivisions in humans. Some have suggested this reflects a unique adaptation in humans, as similar sex differences in corpus callosum morphology have not been reported in any other species of primate examined to date. Furthermore, an association between various measurements of corpus callosum morphology and handedness has been found in humans and chimpanzees. In the current study, we report measurements of corpus callosum cross-sectional area from midsagittal MR images collected in vivo from 14 adult capuchin monkeys, 9 of which were also characterized for hand preference on a coordinated bimanual task. Adult females were found to have a significantly larger corpus callosum: brain volume ratio, rostral body, posterior midbody, isthmus, and splenium than adult males. Left-handed individuals had a larger relative overall corpus callosum area than did right-handed individuals. Additionally, a significant sex and handedness interaction was found for anterior midbody, with right-handed males having a significantly smaller area than right-handed females. These results suggest that sex and handedness influences on corpus callosum morphology are not restricted to Homo sapiens.

Original languageEnglish (US)
Article numbere792
JournalPloS one
Volume2
Issue number8
DOIs
StatePublished - Aug 29 2007
Externally publishedYes

ASJC Scopus subject areas

  • General

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