Copper deficiency alters collagen types and covalent cross-linking in swine myocardium and cardiac valves

R. K. Vadlamudi, R. J. McCormick, D. M. Medeiros, J. Vossoughi, M. L. Failla

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Dietary copper deficiency induces alterations of connective tissue metabolism that are associated with lesions in cardiovascular and other organ systems. To determine the impact of copper deficiency on characteristics of collagen in porcine myocardium and cardiac valves, weaned pigs were fed diets with adequate or deficient levels of copper. Although dietary copper did not affect the concentration of collagen in either myocardium or bicuspid valves, the degree of collagen cross-linking, as assessed by the level of hydroxylysylpyridinoline, was lower in both tissues of copper-deficient pigs. Proportions of type III collagen were increased in the left ventricle and bicuspid valves of copper-deficient pigs. Copper deficiency induced extensive remodeling, however, of the collagen fraction of cardiac interstitium. Reduction in left ventricular collagen cross-linking may provide the stimulus for the development of cardiac hypertrophy, which characterizes severe copper deficiency, by increasing the compliance of the ventricular wall. The shift in the phenotypic profile of collagen that is associated with this cardiac hypertrophy indicates synthesis of new collagen, which could affect collagen cross-linking irrespective of copper status.

Original languageEnglish (US)
Pages (from-to)H2154-H2161
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number6 33-6
StatePublished - 1993
Externally publishedYes


  • cardiac hypertrophy
  • cardiac muscle
  • heart valve

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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