Coordinated Regulation of Axonal Microtubule Organization and Transport by Drosophila Neurexin and BMP Pathway

Swati Banerjee, Maeveen Riordan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Neurexins are well known trans-synaptic cell adhesion molecules that are required for proper synaptic development and function across species. Beyond synapse organization and function, little is known about other roles Neurexins might have in the nervous system. Here we report novel phenotypic consequences of mutations in Drosophila neurexin (dnrx), which alters axonal microtubule organization and transport. We show that dnrx mutants display phenotypic similarities with the BMP receptor wishful thinking (wit) and one of the downstream effectors, futsch, which is a known regulator of microtubule organization and stability. dnrx has genetic interactions with wit and futsch. Loss of Dnrx also results in reduced levels of other downstream effectors of BMP signaling, phosphorylated-Mad and Trio. Interestingly, postsynaptic overexpression of the BMP ligand, Glass bottom boat, in dnrx mutants partially rescues the axonal transport defects but not the synapse undergrowth at the neuromuscular junctions. These data suggest that Dnrx and BMP signaling are involved in many diverse functions and that regulation of axonal MT organization and transport might be distinct from regulation of synaptic growth in dnrx mutants. Together, our work uncovers a novel function of Drosophila Neurexin and may provide insights into functions of Neurexins in vertebrates.

Original languageEnglish (US)
Article number17337
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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Microtubules
Drosophila
Synapses
Bone Morphogenetic Protein Receptors
Axonal Transport
Ships
Neuromuscular Junction
Cell Adhesion Molecules
Nervous System
Glass
Vertebrates
Ligands
Mutation
Growth

ASJC Scopus subject areas

  • General

Cite this

Coordinated Regulation of Axonal Microtubule Organization and Transport by Drosophila Neurexin and BMP Pathway. / Banerjee, Swati; Riordan, Maeveen.

In: Scientific Reports, Vol. 8, No. 1, 17337, 01.12.2018.

Research output: Contribution to journalArticle

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