Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1.

J. Lem, A. C. Chin, M. J. Thayer, Robin J Leach, R. E. Fournier

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Tissue-specific extinguisher-1 (Tse-1) is a mouse genetic locus that can repress liver-specific tyrosine aminotransferase gene expression in trans. To search for other Tse-1-responsive genes, hepatoma microcell hybrids retaining mouse chromosome 11 or human chromosome 17, containing murine Tse-1 and human TSE1, respectively, were screened for expression of liver-specific mRNAs. While most liver gene activity was unaffected in such hybrids, phosphoenolpyruvate carboxykinase and tyrosine aminotransferase gene expression was coordinately repressed in these clones. Extinction of both genes was apparently mediated by a single genetic locus that resides on human chromosome 17.

Original languageEnglish (US)
Pages (from-to)7302-7306
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number19
StatePublished - Oct 1988
Externally publishedYes

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Tyrosine Transaminase
Chromosomes, Human, Pair 17
Genetic Loci
Human Chromosomes
Liver
Enzymes
Genes
Gene Expression
Chromosomes, Human, Pair 11
Phosphoenolpyruvate
Hepatocellular Carcinoma
Clone Cells
Messenger RNA

ASJC Scopus subject areas

  • General
  • Genetics

Cite this

Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1. / Lem, J.; Chin, A. C.; Thayer, M. J.; Leach, Robin J; Fournier, R. E.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 85, No. 19, 10.1988, p. 7302-7306.

Research output: Contribution to journalArticle

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