Convergent functional architecture of the superior parietal lobule unraveled with multimodal neuroimaging approaches

Jiaojian Wang, Yong Yang, Lingzhong Fan, Jinping Xu, Changhai Li, Yong Liu, Peter T Fox, Simon B. Eickhoff, Chunshui Yu, Tianzi Jiang

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The superior parietal lobule (SPL) plays a pivotal role in many cognitive, perceptive, and motor-related processes. This implies that a mosaic of distinct functional and structural subregions may exist in this area. Recent studies have demonstrated that the ongoing spontaneous fluctuations in the brain at rest are highly structured and, like coactivation patterns, reflect the integration of cortical locations into long-distance networks. This suggests that the internal differentiation of a complex brain region may be revealed by interaction patterns that are reflected in different neuroimaging modalities. On the basis of this perspective, we aimed to identify a convergent functional organization of the SPL using multimodal neuroimaging approaches. The SPL was first parcellated based on its structural connections as well as on its resting-state connectivity and coactivation patterns. Then, post hoc functional characterizations and connectivity analyses were performed for each subregion. The three types of connectivity-based parcellations consistently identified five subregions in the SPL of each hemisphere. The two anterior subregions were found to be primarily involved in action processes and in visually guided visuomotor functions, whereas the three posterior subregions were primarily associated with visual perception, spatial cognition, reasoning, working memory, and attention. This parcellation scheme for the SPL was further supported by revealing distinct connectivity patterns for each subregion in all the used modalities. These results thus indicate a convergent functional architecture of the SPL that can be revealed based on different types of connectivity and is reflected by different functions and interactions.

Original languageEnglish (US)
Pages (from-to)238-257
Number of pages20
JournalHuman Brain Mapping
Volume36
Issue number1
DOIs
StatePublished - Jan 1 2015

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Parietal Lobe
Neuroimaging
Visual Perception
Brain
Short-Term Memory
Cognition

Keywords

  • Behavioral domains analyses
  • Coactivation
  • Functional connectivity
  • Parcellation
  • Structural connectivity

ASJC Scopus subject areas

  • Clinical Neurology
  • Anatomy
  • Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Convergent functional architecture of the superior parietal lobule unraveled with multimodal neuroimaging approaches. / Wang, Jiaojian; Yang, Yong; Fan, Lingzhong; Xu, Jinping; Li, Changhai; Liu, Yong; Fox, Peter T; Eickhoff, Simon B.; Yu, Chunshui; Jiang, Tianzi.

In: Human Brain Mapping, Vol. 36, No. 1, 01.01.2015, p. 238-257.

Research output: Contribution to journalArticle

Wang, J, Yang, Y, Fan, L, Xu, J, Li, C, Liu, Y, Fox, PT, Eickhoff, SB, Yu, C & Jiang, T 2015, 'Convergent functional architecture of the superior parietal lobule unraveled with multimodal neuroimaging approaches', Human Brain Mapping, vol. 36, no. 1, pp. 238-257. https://doi.org/10.1002/hbm.22626
Wang, Jiaojian ; Yang, Yong ; Fan, Lingzhong ; Xu, Jinping ; Li, Changhai ; Liu, Yong ; Fox, Peter T ; Eickhoff, Simon B. ; Yu, Chunshui ; Jiang, Tianzi. / Convergent functional architecture of the superior parietal lobule unraveled with multimodal neuroimaging approaches. In: Human Brain Mapping. 2015 ; Vol. 36, No. 1. pp. 238-257.
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