Controversies in lung transplantation: Are two lungs better than one?

Denis Hadjiliadis, Luis F. Angel

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations


Lung transplantation is commonly used for patients with end-stage lung disease. However, there is continuing debate on the optimal operation for patients with chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. Single-lung transplantation (SLT) provides equivalent short- and medium-term results compared with bilateral lung transplantation (BLT), but long-term survival appears slightly better in BLT recipients (especially in patients with COPD). The number of available organs for lung transplantation also influences the choice of operation. Recent developments suggest that the organ donor shortage is not as severe as previously thought, making BLT a possible alternative for more patients. Local expertise and waiting list issues are important in influencing the choice of SLT versus BLT. Most of the data support the use of BLT for the majority of COPD patients when available, and the use of SLT for the majority of idiopathic pulmonary fibrosis (IPF) patients. The ultimate choice of operation will depend on donor and recipient characteristics and local expertise and waiting list issues.

Original languageEnglish (US)
Pages (from-to)561-566
Number of pages6
JournalSeminars in Respiratory and Critical Care Medicine
Issue number5
StatePublished - Oct 1 2006


  • Chronic obstructive pulmonary disease
  • Idiopathic pulmonary fibrosis
  • Lung transplantation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine


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