Controlled microstructuring of janus particles based on a multifunctional poly(ethylene glycol)

Ekaterina Sokolovskaya, Jaewon Yoon, Asish C. Misra, Stefan Bräse, Jörg Lahann

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

A novel water insoluble, multifunctional poly(ethylene glycol), poly(hydrazide ethylene glycol-co-benzyl glycidyl ether) (P(HZ-co-BnGE)), is synthesized via thiol-ene click reaction of poly(allyl glycidyl ether-co-benzyl glycidyl ether) (P(AGE-co-BnGE)). The base polymer P(AGE-co-BnGE) is previously prepared by anionic ring-opening copolymerization of the corresponding monomers. To demonstrate utility, bicompartmental microspheres and microcylinders containing P(HZ-co-BnGE) in one of the compartments are prepared via electrohydrodynamic (EHD) co-jetting. Next, spatially controlled surface reactivity toward sugars is demonstrated by selective binding of 2α-mannobiose to the P(HZ-co-BnGE) compartment only, as confirmed by a carbohydrate-lectin-binding assay. These sugar-reactive hydrazide-presenting microparticles have potential applications for glyco-targeted drug delivery. A new hydrophobic PEG-based polymer with hydrazide groups is synthesized. Anisotropic microparticles containing this polymer in just one compartment are prepared and enable successful immobilization of a sugar followed by subsequent conjugation of a sugar-binding protein. These new multifunctional microparticles are potential carriers for drug delivery enhanced by glycol-targeting.

Original languageEnglish (US)
Pages (from-to)1554-1559
Number of pages6
JournalMacromolecular Rapid Communications
Volume34
Issue number19
DOIs
StatePublished - Oct 2013
Externally publishedYes

Keywords

  • functional materials
  • microparticles
  • poly(ethylene glycol)
  • ring-opening polymerization
  • sugar conjugation

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Controlled microstructuring of janus particles based on a multifunctional poly(ethylene glycol)'. Together they form a unique fingerprint.

Cite this