The role of testosterone-estradiol binding globulin (TeBG) in the control of free estradiol (E2) and testosterone has been shown in the human but its role in the control of free E2 in the non-human primate, which is speculative, was examined in sera collected from sex female baboons during a complete menstrual cycle. Total E2 was estimated by radioimmunoassay, percentage free E2 by equilibrium dialysis and sex skin monitored daily. The percentage free E2 showed little alteration over the cycle (4-6%) and TeBG concentration was maximal 8 days before ovulation. Maximum sex skin turgescence coincided with peak total and free E2 concentrations. TeBG had no apparent control over free E2. It is speculated that it is controlled by non-specific binding proteins whose low affinity interaction with E2 would facilitate rapid dissociation, thus maintaining a dynamic equilibrium between the free and bound components at any given concentration of total E2.
|Original language||English (US)|
|Number of pages||2|
|Journal||IRCS Medical Science|
|State||Published - Jan 1 1986|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)