Control of Candida albicans morphology and pathogenicity by post-transcriptional mechanisms

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations

Abstract

Candida albicans is a major human fungal pathogen responsible for both systemic and mucosal infections in a wide variety of immunocompromised individuals. Because the ability of C. albicans to undergo a reversible morphological transition from yeast to filaments is important for virulence, significant research efforts have focused on mechanisms that control this transition. While transcriptional and post-translational mechanisms have been well-studied, considerably less is known about the role of post-transcriptional mechanisms. However, in recent years several discoveries have begun to shed light on this important, but understudied, area. Here, I will review a variety of post-transcriptional mechanisms that have recently been shown to control C. albicans morphology, virulence and/or virulence-related processes, including those involving alternative transcript localization, mRNA stability and translation. I will also discuss the role that these mechanisms play in other pathogens as well as the potential they may hold to serve as targets for new antifungal strategies. Ultimately, gaining a better understanding of C. albicans post-transcriptional mechanisms will significantly improve our knowledge of how morphogenesis and virulence are controlled in fungal pathogens and open new avenues for the development of novel and more effective antifungals.

Original languageEnglish (US)
Pages (from-to)4265-4278
Number of pages14
JournalCellular and Molecular Life Sciences
Volume73
Issue number22
DOIs
StatePublished - Jun 16 2016

Keywords

  • Alternative transcript localization
  • Antifungal strategies
  • C. albicans
  • Morphogenesis
  • Translational control
  • Virulence
  • mRNA stability

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Fingerprint Dive into the research topics of 'Control of Candida albicans morphology and pathogenicity by post-transcriptional mechanisms'. Together they form a unique fingerprint.

Cite this