Control of a Candida glabrata prosthetic endovascular infection with posaconazole

G. M. Anstead, M. Martinez, John R. Graybill

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A 63-year-old man with a history of cirrhosis of the liver developed Candida glabrata fungemia after undergoing transjugular intrahepatic portosystemic shunt (TIPS) placement. Treatment with oral fluconazole was initially effective, but when the patient became neutropenic, subsequent blood cultures grew C. glabrata and a thrombus developed, which partially occluded the stent. Despite treatment with fluconazole, blood cultures remained positive for C. glabrata. Treatment with posaconazole resulted in clinical improvement and the patient had only intermittently positive fungal cultures for 6 weeks. A CT scan showed resolution of the inferior vena cava thrombus. Subsequently, the patient developed hepatocellular carcinoma and hepatic encephalopathy and became noncompliant with posaconazole. Blood cultures again became positive for C. glabrata. The patient died a few weeks after the diagnosis of hepatocellular carcinoma, but the cause of death was believed to be worsening liver dysfunction, not C. glabrata infection. Posaconazole had controlled the infection for about 3 months prior to his death. In conclusion, posaconazole may be a useful option in the management of prosthetic endovascular infections caused by C. glabrata.

Original languageEnglish (US)
Pages (from-to)273-277
Number of pages5
JournalMedical mycology
Volume44
Issue number3
DOIs
StatePublished - May 2006

Keywords

  • Candida glabrata
  • Infection
  • Posaconazole
  • Transjugular intrahepatic portosystemic shunt

ASJC Scopus subject areas

  • Infectious Diseases

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