Contributions of B cells to lupus pathogenesis

Allison Sang; Ying Yi Zheng; Laurence Morel

doi:10.1016/j.molimm.2013.11.013

Contributions of B cells to lupus pathogenesis

Allison Sang, Ying Yi Zheng, Laurence Morel

Research output: Contribution to journal › Review article › peer-review

54 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.

Original language	English (US)
Pages (from-to)	329-338
Number of pages	10
Journal	Molecular Immunology
Volume	62
Issue number	2
DOIs	https://doi.org/10.1016/j.molimm.2013.11.013
State	Published - Dec 1 2014
Externally published	Yes

Keywords

Autoimmunity
B cells
Lupus

ASJC Scopus subject areas

Immunology
Molecular Biology

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10.1016/j.molimm.2013.11.013

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title = "Contributions of B cells to lupus pathogenesis",

abstract = "Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.",

keywords = "Autoimmunity, B cells, Lupus",

author = "Allison Sang and Zheng, {Ying Yi} and Laurence Morel",

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AU - Sang, Allison

AU - Zheng, Ying Yi

AU - Morel, Laurence

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N2 - Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.

AB - Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.

KW - Autoimmunity

KW - B cells

KW - Lupus

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JO - Molecular Immunology

JF - Molecular Immunology

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Contributions of B cells to lupus pathogenesis

Abstract

Keywords

ASJC Scopus subject areas

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