Contributions of B cells to lupus pathogenesis

Allison Sang, Ying Yi Zheng, Laurence Morel

Research output: Contribution to journalReview articlepeer-review

49 Scopus citations

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.

Original languageEnglish (US)
Pages (from-to)329-338
Number of pages10
JournalMolecular Immunology
Volume62
Issue number2
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

Keywords

  • Autoimmunity
  • B cells
  • Lupus

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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